Biological Trace Element Research

About this book

A well-planned study of biological trace elements requires a multidisciplinary strategy and total quality control from experimental design to collection of valid samples, chemical analysis, data evaluation, and interpretations. To develop a reliable database for the elemental content and speciation of biological systems, analytical chemists, life scientists, and statisticians must plan studies together. This new volume stresses the need for this multidisciplinary approach through discussion of such topics as planning considerations, quality assurance, analytical methods, and speciation and bioavailability.

Contents

The Need for Multidisciplinary Approaches in Biological Trace Element Research; Bioavailability Considerations in Planning Dietary Intake Studies; The Planning of In Vivo Body Composition Studies in Humans; In Vitro Investigations in Biological Trace Element Analysis: Positive and Negative Aspects; Biologically Related National Institute of Standards and Technology Standard Reference Materials: Variability in Concentration Estimates; The Importance of Chemometrics in Biomedical Measurements; Establishing Quality Measurements for Inorganic Analysis of Biomaterials; Evaluation and Improvement of Nutrient Composition Data for Trace Elements in Foods; Trace Metal Analysis and Quality Assurance in Clinical Chemistry; Accuracy and Presicion of Trace Metal Determinations in Biological Fluids: Interlaboratory Comparison Program; Trace Elements in Biological Fluids: Stabilized Temperature Platform Furnace Atomic Absorption Spectrometry; Determination and Speciation of Trace Elements in Biomedical Applications: Inductively Coupled and Other Plasma Sources; Analytical Method Aspects of Assessing Dietary Intake of Trace Elements; Direct Analysis of Biological Samples by Simultaneous Multielement Analysis: Atomic Absorption Spectrometry with Miniature Cup Solid Sampling; Arsenic, Bismuth, Copper, Lead, Nickel, and Selenium in Some Biological Samples: Graphite Furnace Atomization-Atomic Absorption Spectrometry; In Vivo and Biochemical Determination of Toxic Cadium in Rats; Trace Elements in National Institute for Environmental Studies Standard Reference Materials: Instrumental Neutron Activation Analysis; Selenium in Human Serum: Rapid Wet-Ashing and High Performance Liquid Chromatogaphic-Fluorometric Method; Speciation Chemistry of Foods: Problems and Prospects; Biological Reference Materials for Metal Speciation: National Institute for Environmental Standards; Fish Tissue Reference Material for Organotin Compounds; Protein Determination: Neutron Activation Analysis Combined with Biological Isolation Techniques; Synchrotron Radiation and Its Application to Chemical Speciation; Comparative Intestinal Absorption and Subsequent Metabolism of Metal Amino Acid Chelates and Inorganic Metal Salts; Mineral Supplementation in Plants Via Amino Acid Chelation; Trace Element-Induced Toxicity in Cultured Heart Cells; Zinc Status of Low Birth Weight Infants: Stable Isotope Dilution

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