Cell Behaviour: Control and Mechanism of Motility

About this book

Describes the latest molecular and genetic advances in the study of one of the most fundamental, and yet least understood, processes of life: the movement of cells.

Contents

Part 1 Introduction: patterns of cellular activities based on protein sorting in cell motility, endocytosis and cytokinesis. Part 2 Motile responses: new depths in cell behaviour - reactions of cells to nanotopography; self-organization of tissue-equivalents - the nature and role of contact guidance; extracellular regulation of cancer invasion - the E-cadherin/cantenin and other pathways. Part 3 Signal transduction: towards a structure model of an integrin; integrin-mediated cell adhesion - the cytoskeletal connection; Wnt factors in axonal remodelling and synaptogenesis; Rho family proteins and cell migration; Rho-like GTPases - their role in cell adhesion and invasion. Part 4 Cytoskeletal dynamics: microtubule involvement in regulating cell contractility and adhesion-dependent signalling - a possible mechanism for polarization of cell motility; organization and polarity of actin filament networks in cells - implications for the mechanism of myosin-based cell motility; network contraction model for cell translocation and retrograde flow; centrosomes, microtubules and cell migration; cell migration as a five-step cycle. Part 5 Dynamics of motility: cytoskeletal protein mutations and cell motility in "Dictyostelium"; cell crawling two decades after Abercrombie; using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts; forces in cell locomotion. Part 6 Prospects: a dozen questions about how tissue cells crawl.

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