Cellular Responses to Stress

About this book

Provides state of the art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents.

Contents

Preface vii Abbreviations ix 1 Signal transduction by the c-Jun N-terminal kinase By R.J. Davis 1 2 Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress By D.G. Hardie 13 3 Making the connection: coupling of stress-activated ERY,/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses By J.M. Kyriakis 29 4 Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts By J.B.A. Millar 49 5 Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor By J. Saklatvala, J. Dean and A. Finch 63 6 Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2) -dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27) By J. Landry and J. Huot 79 7 DNA-dependent protein kinase and related proteins By G.C.M. Smith, N. Divecha, N.D. Lakin and S.P. Jackson 91 8 Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors By J.J. Cotto and R.I. Morimoto 105 9 Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response By B. Demple. E. Hidalgo and H. Ding 119 10 Adaptive responses to environmental chemicals By C.R. Wolf, G. Smith, A.G. Smith, K. Brown and C.J. Henderson 129 11 Cellular response to cancer chernopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress By J.D. Hayes, E.M. Ellis, G.E. Neal, D.J. Harrison and M.M. Manson 141 Subject index 169

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