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The binding of proteins to DNA and the manipulation of DNA by proteins in such processes as recombination, transcription and topoisomerization are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved, with the emphasis on our current understanding of the structural and mechanistic basis of these phenomena in both bacteria and higher organisms. Among the questions addressed are: how do proteins recognize specific DNA sequences and structures; how do they melt short regions of DNA prior to transcription and DNA replication; how do DNA binding proteins cooperate to regulate transcription; how is DNA packaged in chromatin, and what is the relevance of DNA structure and topology to these processes? The text assumes a knowledge of basic molecular biology and is suitable for research students and final year undergraduates. This book should be of interest to advanced undergraduate and postgraduate students and research workers in biochemistry, molecular biology and genetics.
DNA structure; DNA-protein interactions - the three-dimensional architecture of DNA-protein complexes; DNA-protein interactions - sequence specific recognition; the mechanisms of DNA chain initiation; the regulation of promoter selectivity in eubacteria; the mechanism of eukaryotic transcription; chromatin and transcription.
The value of this analysis is found in the insight it provides into the mechanism of complex systems... the text is generally well-written and flows smoothly. [this work] is full of insights and stimulating in its unification of structure and function, a perspective that is increasingly inmportant in molecular biology. Trends in Genetics; Andrew Travers has done an excellent job of selecting examples illustrating the central theme of the book...the figures are instructive, well designed and selected...I wholeheartedly recommend this book for all structural and molecular biologists who are interested in the biological role of DNA - Trends in Biochemical Sciences; ...the book does bring together areas in a juxtaposition unique to its author...explained with the authority one would expect from Travers. - Nature; ...the book quickly takes us beyond the straightforward undergraduate texts, to provide a helpful source of information and discussion material for advanced undergraduate or Masters'courses. Journal of Biological Education; The value of this analysis is found in the insight it provides into the mechanism of complex systems... the text is generally well-written and flows smoothly. [this work] is full of insights and stimulating in its unification of structure and function, a perspective that is increasingly r portant in molecular biology. Trends in Genetics; Overall, this is a densely detailed text and worth its place on the shelf of practitioners in the field who wish to maintain an overall view...gathers together current knowledge in a useful way - Current Biology
