DNA Replication in Eukaryotic Cells

About this book

DNA replication is an important part in the machinery of cell and viral proliferation. After significant advances in the past few years, its regulation is now more fully understood. This text provides a detailed and up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts. "Concepts" is a distillation of underlying principles, "Proteins" offers a description of each protein class involved, and "Systems" gives a review of events over a wide range of organisms. The book is aimed at teachers who want a current survey of a topic central to the biology syllabus, investigators of replication who require a source of knowledge in their specialty, and scientists studying other biological functions on which DNA replication has an impact.

Contents

DNA replication mechanisms, G.S. Brush, T.J. Kelly; replication origins that function in eukaryotic cells, M.L. DePamphilis; role of transcription factors in DNA replication, P.C. van der Vliet; roles of nuclear structure in DNA replication, R. Laskey, M. Madine; mechanisms for priming DNA synthesis, M. Salas, et al; mechanisms for completing DNA replication, D. Bastia; fidelity of eukaryotic DNA replication, J.D. Roberts, T.A. Kunkel; DNA excision repair pathways in eukaryotes, E.C. Friedberg, R.D. Wood; chromatin structure and DNA replication - implications for transcriptional activity, A.P. Wolffe; phosphorylation in DNA replication, E. Fanning; control of S phase in yeast and animal cells, K. Nasmyth; temporal order of DNA replication, I. Simon, H. Cedar; changes in DNA replication during animal development, J.L. Carminati, T.L. Orr-Weaver; comparison of DNA replication in cells from prokarya and eukarya, B. Stillman; cellular DNA polymerases, T.S.F. Wang; viral DNA polymerases, D.M. Coen; DNA replication accessory proteins, U. Huebscher, et al; DNA helicases, J.A. Borowiec; DNA ligases, R. Nash, T. Lindahl; eukaryotic DNA topoisomerases, A. Hangaard Anderson, et al; structure and biochemistry of ciliate and mammalian telomerases, C.W. Greider, et al; papovaviruses, J. Hassell. (Part contents).

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