By: Andy Bates and Tony Maxwell
192 pages, 64 illus
DNA as the genetic material is a topic of intense interest in the 21st century with the familiar and iconic Watson-Crick double helix having a vital importance for its function. However, there are further complexities beyond the double helix, including supercoiling, knotting and catenation, that are less widely appreciated and understood but which are critical to its function.
DNA Topology provides a solid basis for understanding the physical properties of DNA and its topology, and how this molecule actively participates in many cellular processes. This book is certainly aimed at specialists, whom it will not diappoint with its detailed treatment of the core subject matter. The Quarterly Review of Biology, Volume 81, March 2006.
1. DNA structure; 2. DNA supercoiling; 3. DNA on surfaces; 4. Knots and catenanes; 5. DNA topoisomerases; 6. Biological consequences of DNA topology
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