About this book
Dynamics of Bone and Cartilage Metabolism is a comprehensive treatise that spans the complete range from basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. Part I of the book provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components, including the important regulators such as cytokines, growth factors, and proteases. The second part of the book covers the organizational structure and cellular metabolism of bone and cartilage. As with the first part, there are separate sections on bone and cartilage addressing their specific and unique functions. For bone, questions on mineralization, remodeling and hormonal regulation are covered as well as the derivation of products of metabolism: for cartilage, the physiology and pathology are reviewed in relation to the products of metabolism, together with recent data from animal and in vitro models. The first two parts of the book serve to contextualize all of the biochemical markers for assessing bone and cartilage metabolism. Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease, both in experimental and clinical settings. A wide range of disorders affecting bone and cartilage metabolism is covered, including different forms of osteoporosis, metastatic bone disease and arthritic diseases, as well as some of the less common growth and degenerative abnormalities. This application-oriented part of the book is complemented by an initial section detailing the methodological and technical aspects of the various biochemical and genetic markers of disease and their measurements. With contributions from over 75 international experts, this book will be indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of the patient with bone and cartilage diseases.
Contents
K. von der Mark, Structure and Biosynthesis of Collagens. S.P. Robins, Fibrillogenesis and Maturation of Collagens. C.M. Gundberg and K. Nishimoto, Vitamin K Dependent Proteins of Bone and Cartilage. D. Heinegard, T. Saxne, and P. Lorenzo, Non-Collagenous Proteins: Glycoproteins and Related Molecules. T.E. Hardingham, Proteoglycans and Glycosaminoglycans. G. Russell and P. Croucher, Regulatory Components: Growth Factors. L. Raisz and J. Lorenzo, Cytokines and Prostaglandins. M.H. Helfrich and M.A. Horton, Integrins and Adhesion Molecules. P. Henthorn, P. Leboy, and J.L. Millán, Acid and Alkaline Phosphatases. I.M. Clark and G. Murphy, Matrix Proteases. A.L. Boskey, Mineralization, Structure, and Function of Bone. J.B. Lian and G. Stein, The Cells of Bone. L.A. Fitzpatrick and J.P. Bilezikian, Parathyroid Hormone. D. Goltzman and A.C. Karaplis, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: PTHrP: Of Molecules, Mice, and Men. R. Bouillon, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Vitamin D. S. Khosla and B.L. Riggs, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Sex and Steroid Effects on Bone Metabolism. R. Rizzoli and J.-P. Bonjour, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology of Calcium and Phosphate Homeostasis. D.W. Dempster, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: New Concepts in Bone Remodeling. J. Risteli and L. Risteli, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Bone Collagen Metabolism. P. Bruckner and E.F. Eikenberry, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Supramolecular Structure of Cartilage Matrix. M.T. Bayliss, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Physiology and Pathology of Cartilage Metabolism. D.-H. Manicourt, Structure and Metabolism of the Extracellular Matrix of Bone and Cartilage: Products of Cartilage Metabolism. P.A. Simkin, Fluid Dynamics of the Joint Space Trafficking of Matrix Breakdown Products. H.J. Häuselmann, In Vitro Models of Cartilage Metabolism. R.D. ALtman and C.J. Lozada, Animal Models of Cartilage Breakdown. H.A.P. Pols, J.P.T.M. van Leeuwen, and A.G. Uitterlinden, Genetic Approaches to Metabolic Bone Disease. H. Schmidt-Gayk, Measurement of Local and Systemic Regulators of Bone Metabolism. R. Eastell and K.E. Naylor, Measurement of Biochemical Markers of Bone Formation. M.E. Kraenzlin and M.J. Seibel, Measurement of Biochemical Markers of Bone Resorption. E.F. Eriksen and K. Brixen, Validation of Local and Systematic Markers of Bone Turnover.; S. Gay, M. Neidhart, and R.E. Gay, Genetic Markers of Joint Disease. E.J. Thonar, M.E. Lenz, K. Masuda, and D.-H. Manicourt, Markers of Cartilage Metabolism. P.J. Delmas and P. Garnero, Postmenopausal Osteoporosis. C. Rosen, Age-Related Osteoporosis. E.S. Orwoll, Osteoporosis in Men. I.R. Reid, Steroid Induced Osteoporosis. E. Shane, Secondary Osteoporosis. M.K. Drezner, Osteomalacia and Rickets. K.J. Martin and E.A. Gonzalez, Renal Osteodystrophy. S.J. Silverberg and J.P. Bilezikian, Primary Hyperparathyroidism. A. Grauer and E.S. Siris, Paget's Disease of Bone. J.-J. Body, Metastatic Bone Disease. M.P. Whyte, Rare Bone Diseases. S.R. Goldring and M.B. Goldring, Rheumatoid Arthritis and Other Inflammatory Joint Pathologies. K. Akesson, Osteoarthritis and Degenerative Spine Pathologies. J.M. Gertner, Normal and Abnormal Growth and Development.
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Biography
Dr. Bilezikian, Professor of Medicine and Pharmacology at the College of Physicians and Surgeons, Columbia University is the Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia-Presbyterian Medical Center. He also serves as Associate Chair, Department of Medicine. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians and Surgeons. He completed four years of house staff training (internship and residency) including the Chief Medical Residency of the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH where he served as a Clinical Associate in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies, including the American Society for Bone and Mineral Research, of which he served as President in 1996. He is a member of the Endocrine Society, the American Federation for Clinical Research, the American Society for Clinical Investigation, the Association of American Physicians, the American Association of Clinical Endocrinologists, the American Society for Pharmacology and Experimental Therapeutics, and the International Society of Clinical Densitometry, of which he is President. He is Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism. His books include Editor-in-Chief of The Parathyroids (1994), and co-editor of Principles of Bone Biology (1996), The Aging Skeleton (1999), and Dynamics of Bone and Cartilage Metabolism (1999). He has been on numerous panels, including serving as Chair of the NIH Consensus Development Panel on Optimal Calcium Intake, and the Food and Nutrition Board of the National Academy of Sciences. He is a major national and international spokesperson for the field of metabolic bone diseases. Dr. Bilezikian's major research interests are related to the clinical investigation of metabolic bone diseases, particularly osteoporosis and primary hyperparathyroidism. His is the recipient of the Distinguished Physician Award of the Endocrine Society and of the Frederic C. Bartter Award of the American Society for Bone and Mineral Research for Excellence in the Clinical Research. He also has an active laboratory program in the biochemical mechanisms of the hormones that regulate calcium metabolism. His publications, which number of 350, speak to his active original investigative initiatives as well as his demand as an author of many reference sources of endocrinology and metabolic bone diseases. Markus J. Seibel completed a medical degree and a doctoral degree in 1984 from the University of Mainz, Germany and the University of Pennsylvania, Philadelphia. Since 1996, he has been the head of the Endocrine Laboratories at Heidelberg University, Germany and a consultant in Endocrinology. Since 1997, he has been an Associate Professor and Member of the Faculty of Medicine at the University of Heidelberg and as of 1999, he will be Associate to the Director of the Department of Endocrinology and Metabolism. His research interests include bone and cartilage metabolism, treatment of osteoporosis, and thyroid carcinoma.
