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About this book
The openings offered by functional genomics reconciles organism biology and molecular biology, in order to define an integrative biology that should allow new insights about how a phenotype is built up from a genotype in interaction with its environment.
This book covers a wide area of concepts and methods in genomics. These range from international genome sequencing projects, to invaluable bioinformatics tools, and analytical methods of gene expression, including final metabolic products and their specific tissue and cellular compartmentalization. This new knowledge enables readers to understand the integration of basic physiological functions, and developmental programs. Also, the establishment of tight relationships between genomics, and genetics and plant breeding reveals synergies for exploiting molecular markers, for analysing genetic variation, or for studying quantitative traits. The integration that is now feasible by these new approaches also effects ecophysiology, and opens up new perspectives for the use of modelling for the study of plant populations. This book will contribute to the dissemination of these new practices.
Contents
Structural Genomics and in silico Analysis; * Physical Structure of the Plant Nuclear Genome: M. Delseny et al.; * The Sequencing of Plant Nuclear Genomes: N. Choisne et al.; * Introduction to Bioinformatics: H. Chiapello and F. Rodolphe; * Databases in Biology: H. Chiapello; * Gene Prediction: P. Nicolas and H. Chiapello; * Detecting Protein Function from Genome Sequences: J.F. Gibrat and A. Marin; * Large-scale Protein Sequence Comparisons: J.L. Risler et al.; Functional Genomics: From Sequence to Function in Plants; * Gene Transfer to Plants: Y. Chupeau and R. Davey; * Mutant Libraries: A High-throughput Arabidopsis Reverse Genetics System: F. Granier and D. Bouchez; * DNA Microarrays in Plants: P. Doumas et al.; * Statistical Design and the Analysis of Gene Expression Determined by Independent Component Analysis: A. Riva et al. * Proteomics: M. Zivy et al.; * Tracking Gene Expression in Plant Cells: Microscopy and Associated Bio-imaging Techniques: Spencer Brown et al.; * Tracking Gene Expression in Plant Cells: New Probes for Functional Genomics: S. Bolte et al.; * Metabolomics: A. Krapp et al.; * Metabolic Fingerprinting and Profiling by Proton NMR: A. Moing et al.; * Methods for the Qualitative and Quantitative Analysis of Metabolic Fluxes: M. Dieuaide-Noubhani et al.; * The Structure of Metabolic Networks or (almost) All that is Known about the Simplest Metabolic Network: Jean-Pierre Mazat; Plant Models in Genomics; * The Model Species, Arabidopsis thaliana: X. Johnson and D. Bouchez; * Rice, a Model Plant for Cereal Genomics: M. Delseny; * The Model Medicago truncatula: From Plant-Microbe Symbioses to Crop Legume Breeding Boosted by Cross-Legume Genomics: E.P. Journet and P. Gamas; * Tomato: A Model Plant for Solanaceae Genomics: R. Stevens et al.; * Genomics as a Road for Grapevine Improvement: A.F. Adam-Blondon et al.; * Sugarcane, a Tropical Crop with a Highly Complex Genome: J.Y. Hoarau et al.; Genomics, Genetic Variability and Plants Breeding; * Molecular Markers and High-throughput Genotype Analysis: M. Falque and S. Santoni; * Transposable Elements and the Analysis of Plant Biodiversity: S.M. Tam et al.; * Analysis of Complex Characters into Elementary Components the Use of Molecular Quantitative Genetics in Arabidopsis thaliana: O. Loudet and F. Daniel-Vedele; * Characterisation of Major Genes and QTLs by a Candidate Gene Approach: R. Stevens et al.; * Molecular Evolution and Validation of Candidate Gene: D. Manicacci et al.; * Genomics and Plant Breeding: Maize and Wheat: B. Hirel et al.; Genomics, Agronomy, Technology and Patenting; * From Genomics to Self-assembly: V. Planchot et al.; * Patenting, Licensing and Transfer of Knowledge in Plant Biotechnology: Public-Private Partnerships: B. Teyssendier de la Serve and M. Trommetter; * Glossary: C. Meyer and J.F. Morot-Gaudry; * Index.
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