This textbook offers an articulate, current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format.
Chapter 1 Levels of gene control Chapter 2 Structure of chromatin Chapter 3 Role of chromatin structure in gene control Chapter 4 The process of transcription Chapter 5 Transcription factors and transcriptional control Chapter 6 Post-transcriptional processes Chapter 7 Post-transcriptional regulation Chapter 8 Gene control and cellular signaling pathways Chapter 9 Gene control in embryonic development Chapter 10 Control of cell type-specific gene expression Chapter 11 Gene regulation and cancer Chapter 12 Gene regulation and human disease Chapter 13 Conclusions and future prospects
The range of details probably means that students can jump in and out of the sections as they require, dependent upon their starting knowledge!The overall structure of the book appears to cover the major areas that we focus on, and there is sufficient depth/clarity for 1st and 2nd years. Dr Nick Plant, University of Surrey (referring to Chapter 8 Gene control and cellular signaling pathways) "I feel this text is written such that the content would be easily understood by my medical students. In addition it covers the material with sufficient depth, yet not overly burdensome, for the level of learning of medical students! the author has done an excellent job of balancing basic discussion with complete complex topics." Professor Michael King, Indiana State University (referring to Chapters 1, 2 and 3) "...the level of detail is perfect! I really like the simple figures the author creates. This is one of my favorite features of the current Latchman book I am using. The information is simple and very clear! I really enjoyed reading these chapters and feel students will benefit greatly! This author really presents information clearly and I love the way he organizes the information." Dr Maureen Ferran, Rochester Institute of Technology (referring to Chapters 6 and 7) "Striking this balance (between basic and more complex information) is consistently a strength in this author's books and why I enjoy using the current book in my course. It is quite easy for an instructor to include or exclude information according to the time they have for a particular topic." Dr Maureen Ferran, Rochester Institute of Technology (referring to Chapter 10 Control of cell-type-specific gene expression) "The thing I like about the book is the simplicity of the figures, which my students found very helpful in illustrating complex concepts. I think that the material in this chapter is laid out in a logical manner and has sufficient detail for the way my course is structured." Ava Udvadia, University of Wisconsin-Madison (referring to Chapter 10 Control of cell-type-specific gene expression)
David Latchman is Professor of Genetics and Master of Birkbeck, University of London and Professor of Human Genetics at the Institute of Child Health, University College London. His current teaching includes coursework on Eukaryotic Molecular Biology including Gene control to 200 + second year students at UCL and Masters courses on Gene Regulation to students at Birkbeck. Previous publications include Gene Regulation 5e, Taylor & Francis in 2005, Eukaryotic Transcription Factors 4e, Elsevier, in 2004 and a variety of journal articles. His previous books have a reputation for their clarity of explanation.