Integration of Pharmaceutical Discovery and Development Case Histories

About this book

This volume provides case histories illustrating the types of interdisciplinary interactions necessary to design drug candidates with optimal pharmacological, pharmaceutical, biopharmaceutical, and metabolic/pharmacokinetic properties. Key features include an incisive discussion of HIV protease inhibitors and 287 illustrations.

Contents

Introduction; R. Hirschmann. Renin Inhibitors; S.H. Rosenberg, H.D. Kleinert. The Discovery and Development of Angiotensin II Antagonists; D.J. Carini, et al. Development of an Orally Active Tripeptide Arginal Thrombin Inhibitor; R.T. Shuman, P.D. Gesellchen. Discovery and Development of an Endothelin-A Receptor Selective Antagonist PD 156707; A.M. Doherty, A.C.G. Uprichard. Endothelin Receptor Antagonists; J.D. Elliott, et al. LHRH Antagonists; F. Haviv, et al. LHRH Agonists; K.W. Funk, et al. Discovery and Development of Somatostatin Agonists; P. Marbach, et al. Factors Impacting the Delivery of Therapeutic Levels of Pyrone-Based HIV Protease Inhibitors;; G.E. Padbury, et al. The Integration of Medicinal Chemistry, Drug Metabolism, and Pharmaceutical Research and Development in Drug Discovery and Development: The Story of Crixivan TM, an HIV Protease Inhibitor; J.H. Lin, et al. De Novo Design and Discovery of Cyclic HIV Protease Inhibitors Capable of Displacing the Active-Site Structural Water Molecule; G.V. De Lucca, et al. Discovery and Development of the BHAP Nonnucleoside Reverse Transcriptase Inhibitor Delaviridine Mesylate; W.J. Adams, et al. 12 Additional Chapters. Index.

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