Integrative Approaches to Molecular Biology

About this book

Focuses on molecular biology beyond sequences: from gene regulation to differentiation, a higher-level integration that will be a major theme in biology following the conclusion of the genome project.

Contents

Evolution as engineering, Richard C. Lewontin. Part 1 Computational biology: analysis of bacteriophage T4 based on the completed DNA sequence, Elizabeth Kutter; the identification of protein functional patterns, Temple F. Smith et al; comparative genomics - a new integrative biology, Robert J. Robbins; on genomes and cosmologies, Antoine Danchin. Part 2 Regulation, metabolism and differentiation - experimental and theoretical integration: a kinetic formalism for integrative molecular biology - manifestation in biochemical systems theory and use in elucidating design principles for gene circuits, Michael A. Savageau; genome analysis and global regulation in "escherichia coli", Frederick C. Neidhardt; feedback loops - the wheels of regulatory networks, Rene Thomas; integrative representations of the regulation of gene expression, Julio Collado-Vides; eukaryotic transcription, Thomas Oehler and Leonard Guarente; analysis of complex metabolic pathways, Michael L. Mavrovouniotis; where do biochemical pathways lead?, Jack Cohen and Sean H. Rice; gene circuits and their uses, John Reinitz and David H. Sharp; fallback positions and fossils in gene regulation, Boris Magasanik; the language of the genes, Robert C. Berwick.

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Biography

Julio Collado-Vides is Professor and Head of the Laboratory of Computational Biology at the Universidad Nacional Autonoma de Mexico, Cuernavaca. He is coeditor of Integrative Approaches to Molecular Biology (MIT Press, 1996).