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Sugars are familiar as vital sources of energy. Yet the biological importance of the sugars extends well beyond their value as cellular fuels. "Introduction to Glycobiology" reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level. Employing a two-part structure, the book leads us through essential principles and concepts upon which the discipline is grounded, before exploring the diverse roles of sugars throughout biological systems, including development, cell signalling, and protein trafficking. It also emphasises the importance of glycobiology in disease, and explains how an understanding of the link between the two is enabling us to develop new therapeutic strategies.
Taking the student from the fundamental principles to the frontiers of the subject, and with a wealth of learning features to get the most out of their studies, "Introduction to Glycobiology" remains the ideal resource for students and teachers alike.
New to this edition
- Updated content to reflect the current state of the field: new chapter on cell biology of glycosylation, expanded coverage of congenital disorders, proteoglycans, influenza virus, muscular dystrophy, and cancer - Marginal cross-references between the chemical first part and biological and biomedical second part of the book further emphasise the relevance of structure to function
- New and updated special topic boxes represent the current research and applications of glycobiology to disease and therapeutics
- Broadened treatment of analytical methods, including glycoarrays, provides an overview of the cutting edge techniques used to increase our understanding
- New Journal Clubs feature discussion questions based on research papers and linked to topics featured in the book, to guide the process of assimilating knowledge from the research literature
Part 1: Structures and biosynthesis of glycans
1: Concepts of glycobiology
2: N-Linked glycosylation
3: O-Linked glycosylation
4: Glycolipids and membrane protein glycosylation
5: Enzymology and cell biology of glycosylation
6: Glycomics: analysis of glycan structures
7: Conformations of oligosaccharides
Part 2: Glycans in biology
8: Effects of glycosylation on protein structure and function
9: Carbohydrate recognition in cell adhesion and signalling
10: Glycoprotein trafficking in cells and organisms
11: Glycobiology of plants, bacteria, and viruses
12: Glycobiology and development
13: Glycosylation and disease
14: The future of glycobiology
Maureen Taylor is Senior Lecturer in Molecular Biosciences at Imperial College London and fellow and tutor in biochemistry at Exeter College, Oxford.
Kurt Drickamer is Professor of Biochemistry in the Division of Molecular Biosciences at Imperial College London.
Reviews from the previous edition:
"This book is an absolute must for all lecturers and students alike of glycobiology ... Wholeheartedly recommended."
- Microbiology Today, November 2006
"It covers the breadth of glycobiology very well and provides sufficient depth to provide a platform for further research."
- Dr Gavin M. Brown, Lancaster University
"Others are not written as clearly or concisely as Taylor and Drickamer."
- Prof Y.C. Lee, John Hopkins University
"I prefer this book highly above the other text books available."
- Prof Dr J.P. Kamerling, Utrecht University
"Dr Taylor and Professor Drickamer should be congratulated on writing a textbook that presents the enormous subject of glycobiology with energy and enthusiasm and doing so in a manner that should be accessible to their target audience."
- Biochemist e-volution, April 2006
