Introduction to Immunotoxicology

About this book

Introduction to key immunotoxicological issues such as health consequences - chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune reactions - and methods that can be used to detect and evaluate the unexpected immunotoxic effects of xenobiotics, both preclinically and clinically.

Contents

Part I: Immunotoxic Effects and their Clinical Consequences 1. Definition of Immunotoxicology 2. Overview of the Immune System 3. Immunosuppression and Immunodepression 4. Immunostimulation 5. Hypersensitivity 6. Autoimmunity 7. Major ImmunotoxicantsPart II Immunotoxicity Evaluation 8. Guidelines 9. Histopathology 10. Assays of Humoral Immunity 11. Assays of Cell-Mediated Immunity 12. Assays of Non-Specific Defences 13. Host Resistance Assays 14. Strategies for the Evaluation of Immunosuppression 15.Identification of Chemical Sensitisers 16. Prediction of Autoimmunity Trends and Perspectives in Immunotoxicology 17. Immunotoxicity Risk Assessment 18. New Methods in Immunotoxicology 19. Human Immunotoxicology 20. Immunotoxicology and Wildlife.

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