Introduction to Modern Virology

About this book

Praised for its clarity of presentation and accessibility, Introduction to Modern Virology has been a successful student text for over 30 years. It provides a broad introduction to virology, which includes the nature of viruses, the interaction of viruses with their hosts and the consequences of those interactions that lead to the diseases we see.

This new edition contains a number of important changes and innovations including:
- The consideration of immunology now covers two chapters, one on innate immunity and the other on adaptive immunity, reflecting the explosion in knowledge of viral interactions with these systems.
- The coverage of vaccines and antivirals has been expanded and separated into two new chapters to reflect the importance of these approaches to prevention and treatment.
- Virus infections in humans are considered in more detail with new chapters on viral hepatitis, influenza, vector-borne diseases, and exotic and emerging viral infections, complementing an updated chapter on HIV.  
- The final section includes three new chapters on the broader aspects of the influence of viruses on our lives, focussing on the economic impact of virus infections, the ways we can use viruses in clinical and other spheres, and the impact that viruses have on the planet and almost every aspect of our lives.

A good basic understanding of viruses is important for generalists and specialists alike. The aim of Introduction to Modern Virology is to make such understanding as accessible as possible, allowing students across the biosciences spectrum to improve their knowledge of these fascinating entities.

Contents

Preface xvii
About the companion website xix

PART I THE NATURE OF VIRUSES 1
Chapter 1 Towards a definition of a virus 3
Chapter 2 The structure of virus particles 13
Chapter 3 Classification of viruses 30
Chapter 4 The evolution of viruses 39

PART II VIRUS GROWTH IN CELLS 67
Chapter 5 Techniques for studying viruses 52
Chapter 6 The process of infection: I. Virus attachment and entry into cells 69
Chapter 7 The process of infection: IIA. The replication of viral DNA 86
Chapter 8 The process of infection: IIB. Genome replication in RNA viruses 105
Chapter 9 The process of infection: IIC. The replication of RNA viruses with a DNA intermediate and vice versa 121
Chapter 10 The process of infection: IIIA. Gene expression in DNA viruses and reverse-transcribing viruses 136
Chapter 11 The process of infection: IIIB. Gene expression and its regulation in RNA viruses 156

PART III VIRUS INTERACTIONS WITH THE WHOLE ORGANISM 199
Chapter 12 The process of infection: IV. The assembly of viruses 179
Chapter 13 Innate and intrinsic immunity 201
Chapter 14 The adaptive immune response 218
Chapter 15 Interactions between animal viruses and cells 237
Chapter 16 Animal virus–host interactions 248
Chapter 17 Mechanisms in virus latency 261

PART IV VIRUSES AND HUMAN DISEASE 293
Chapter 18 Transmission of viruses 279
Chapter 19 Human viral disease: an overview 295
Chapter 20 Influenza virus infection 309
Chapter 21 HIV and AIDS 327
Chapter 22 Viral hepatitis 347
Chapter 23 Vector-borne infections 362
Chapter 24 Exotic and emerging viral infections 376
Chapter 25 Carcinogenesis and tumour viruses 388
Chapter 26 Vaccines and immunotherapy: the prevention of virus diseases 409
Chapter 27 Antiviral therapy 431

PART V VIROLOGY – THE WIDER CONTEXT 459
Chapter 28 Prion diseases 443
Chapter 29 The economic impact of viruses 461
Chapter 30 Recombinant viruses: making viruses work for us 472
Chapter 31 Viruses: shaping the planet 484

Index 491

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