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This new edition of "Introduction to the Cellular and Molecular Biology of Cancer" provides a comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalisation, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of this popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field.
This book will be much appreciated by newcomers to cancer biology and will provide a concise and thought-provoking review for experts in the field.--Quarterly Review of Biology
1. What is cancer?; 2. The causes of cancer; 3. Inherited susceptibility to cancer; 4. DNA repair and cancer; 5. Epigenetic events in cancer; 6. Molecular cytogenetics of cancer; 7. Oncogenes; 8. Tumour suppressor genes; 9. The cancer cell cycle; 10. Cellular immortalization and telomerase activation in cancer; 11. Growth factors and their signalling pathways in cancer; 12. Apoptosis: molecular physiology and significance for cancer therapeutics; 13. Mechanisms of viral carcinogenesis; 14. Cytokines and cancer; 15. Hormones and cancer; 16. The spread of tumours; 17. Angiogenesis; 18. Stem cells, heamopoiesis, and leukaemia; 19. Animal models of cancer; 20. The immunology of cancer; 21. The molecular pathology of cancer; 22. From transcriptome to proteome; 23. Local treatment of cancer; 24. Chemotherapy; 25. Radiotherapy and molecular radiotherapy; 26. Monoclonal antibodies and therapy; 27. Immunotherapy of cancer; 28. Cancer gene therapy; 29. Screening; 30. Conclusions and prospects
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