Life Extension Lessons from Drosophila

About this book

Life Extension looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio-gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.

Drosophila models have been developed for a large variety of aging-related processes and diseases, and Life Extension provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine.

This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Contents

Preface Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova

SECTION I: Genetic Regulation of Longevity
CHAPTER 1. Neuronal Genes and Developmental Neuronal Pathways in Drosophila Lifespan Control / Elena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina, Olga Rybina
CHAPTER 2. Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila / Alexey A. Moskalev, Ekaterina N. Plyusnina and Mikhail V. Shaposhnikov
CHAPTER 3. Superoxide Dismutase (SOD) Genes and Aging in Drosophila / John Tower
CHAPTER 4. Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in Drosophila / Oleksandr M. Maistrenko, Svitlana V. Serga, Alexander M. Vaiserman and Iryna A. Kozeretska

SECTION II: Drosophila Models for Aging-Associated Diseases
CHAPTER 5. Skeletal muscle homeostasis and aging in Drosophila / Melissa J. Puppa and Fabio Demontis
CHAPTER 6. Drosophila Models of Cardiac Aging and Disease / Alyson Sujkowski, Chelsea Richardson and Robert Wessells
CHAPTER 7. Parallels between Mammals and Flies in Inflammatory Bowel Disease / Theodoulakis Christofi and Yiorgos Apidianakis
CHAPTER 8. Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in Drosophila / Lorena de Mena, Pedro Fernandez-Funez and Diego E. Rincon-Limas
CHAPTER 9. Drosophila Models in Therapeutic Drug Discovery Related to Aging / Charles Nichols

SECTION III: Life-Extending Treatments
CHAPTER 10. Life-Extending Effect of Phytochemicals in Drosophila / Lee Shin-Hae and Min Kyung-Jin
CHAPTER 11. Life Extension in Drosophila by Histone Deacetylase Inhibitors / Alexander M. Vaiserman and Elena G. Pasyukova
CHAPTER 12. An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail? / Grant A. Rutledge and Michael R. Rose
CHAPTER 13. Atmosphere, Metabolism and Longevity / Khatchik Muradian
CHAPTER 14. Effects of Mild Stresses Applied in Adults on Aging and Longevity / Eric Le Bourg
CHAPTER 15. Strategies for Stage-Specific Extension of Longevity / Robert Arking

Index

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