Books  Animal & General Biology  Biochemistry & Molecular Biology 

Limb Regeneration

Out of Print

Series: Developmental and Cell Biology Series Volume: 31

By: Panagiotis A Tsonis

241 pages, Col & b/w photos, figs, tabs.

Cambridge University Press

Hardback | Sep 1996 | #77257 | ISBN: 0521441498
Out of Print Details

About this book

The complex phenomenon of limb regeneration that occurs in some Amphibia involves unique molecular and cellular mechanisms. When a limb is amputated a new one is produced by the transformation of the remaining adult limb tissues into an embryonic-like cell mass, called the blastema. The blastema has the ability to subsequently redifferentiate into the various tissues that comprise a limb and therefore replace the lost part. It is argued that the same processes that are encountered in normal embryogenesis are reinitiated during regeneration. This is the first book that attempts to describe and analyse the mechanisms of both limb regeneration and patterning by incorporating the information obtained from older experiments with the many new advances in molecular and cellular biology that have occurred in recent years.

This is certainly an interesting book which all readers, even if not interested in the given field, may read because of the elegant manner in which it is written and the numerous interesting points having been evoked. Cellular and Molecular Biology "Extensive and thorough...a worthwhile library purchase." F.W. Yow, Choice


Preface; Prologue; 1. Capacity of limb regeneration in vertebrates; 2. The amputation - the early events; 3. The beginning of regeneration - wound epithelium; 4. Dedifferentiation and origin of the blastema; 5. Differentiation of the blastema; 6. Nerve dependence of regeneration; 7. Protein synthesis in the blastema; 8. Limb cells in vitro; 9. Tissue vs. Epimorphic regeneration; 10. Bioelectricity and limb regeneration; 11. Post-embryonic induction in amphibian limbs; 12. Stimulation and inhibition of regeneration; 13. Genetics and limb regeneration; 14. Models for pattern formation; 15. Morphogenetic properties of the blastema; 16. The regeneration of positional information; 17. Vitamin A and patterning; 18. Hox genes and limb regeneration; 19. Regenerating CSH developing limbs; 20. Molecular advances; References; Index.

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