448 pages, Figs, tabs
Presents the fundamental principles, history, theory, science and applications of microarray technology.
...ideal for those who are interested in a broad introduction to microarrays, one that describes thing literally from the ground up. (American Journal of Physical Anthropology, August 2004) "...a rigorous but reader-friendly critique of diverse ways that genome data can be used in academic and industrial research..." (Genetic Engineering News, Vol. 23, No. 13, July 2003) "...an essential resource for anyone involved in the life sciences...the first textbook treatment of this innovative technique..." (Word Trade) "...an essential resource for anyone involved in the life sciences...the first textbook treatment of this innovative technique..." (Word Trade) "...an excellent text...a valuable reference... If you need to know what microarrays are, how they can be used, how they work, and how you can analyze the data...then this book will provide the insight." (Clinical Chemistry, Vol. 49, No. 6, 2003) "...a very personal, encyclopedic, diffuse compendium of everything known about microarrays...fun to read...full of information that a working biologist...might be quite interested to learn." (ASM News, Vol. 69, No. 7, 2003) "...the book is highly recommended as an excellent one stop resource on microarray technology." (Proteomics, October 2003)
Preface. Introduction to Microarray Analysis. Introduction to Chemistry. Basics of Biochemistry. Genes and Genomes. Microarray Surfaces. Targets and Probes. Microarray Manufacturing. Microarray Detection. Microarray Informatics. Methodological Architecture. Cleanroom Technology. Gene Expression Profiling. Genetic Screening and Diagnostics. Novel Microarray Technologies. Commercial Opportunities A to Z. Future Trends: Chips in the Clinics. Appendix A: Prefixes. Appendix B: Unit Abbreviations. Appendix C: Technical Abbreviations. Appendix D: Conversions. Appendix E: Nucleic Acid Molecular Weight Calculations. Appendix F: Microarray Spot Area Calculations. Appendix G: Microarray Fluor Density Calculations. Appendix H: Microarray Target Density Calculations. Appendix I: Microarray Web Sites. References. Glossary. Answers. Index.
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MARK SCHENA, Ph.D., the "Father of Microarray Technology," trained with Dan Koshland at U.C. Berkeley, Keith Yamamoto at UCSF, and Ron Davis at Stanford University. He published the first paper on microarrays in Science in 1995, and has given more than 80 lectures in 15 countries since 1995. Dr. Schena was featured as one of the Stars of Genomics on the 2001 NOVA television documentary on the Human Genome Project, and is currently a visiting scholar at TeleChem/arrayit.com in Sunnyvale, California.