About this book
Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. The book also deals with the influence of both essential and non-essential transition metals on gene expression and the ability of cells to respond to extracellular signals. It covers the latest information on specific metals and the biological molecules (such as glutathione, metallothioneins, specific transporters, signal transduction proteins, and transcription factors) with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. A volume focusing on this area of research is timely, and makes a fertile meeting ground for the disciplines of molecular genetics and metal toxicology. Zalups; Rudolfs K. Mercer Univ School of Medicine, Macon, Georgia, USA,Koropatnick; D. James London Regional Cancer Center, Ontario, Canada,
Contents
1. Characterising metal ion interactions with biological molecules - the spectroscopy of metallothionein Martin J. Stillman and Anthony Presta 2. Biochemical pathways in cadmium toxicity M.H. Bhattacharyya, A.K. Wilson, S.S. Rajan and M. Jonah 3. Arsenic Eric Wildfang, Shiela M. Healy and Vasken Aposhian 4. Chromium and nickel Max Costa 5. Transport of soft metals in prokaryotes Christopher Rensing and Barry P. Rosen 6. Metal transport and metabolism Michael Didonato and Bibudhendra Sarkar 7. The role of ion channels in the transport of metals into excitable and non-excitable cells Timothy J. Shafer 8. Responses of the respiratory tract to cadmium Beth A. Hart 9. Mercury: molecular interactions and mimicry in the kidney Rudolfs K. Zalups 10. Transport of metals in the nervous system Michael Aschner and Laura E. Kerper 11. Transport of metals in the gastrointestinal system and kidneys Gary L. Diamond 12. Molecular mechanisms of hepatic metal transport Nazzareno Ballatori 13. Role of glutathione in the metabolism, transport and toxicity of metals Lawrence H. Lash 14. Role of metallothionein in the metabolism, transport and toxicity of metals Michael P. Waalkes and Raul Perez-Olle 15. Metal ions and the cytoskeleton Douglas M. templeton 16. The role of metals in oxidative damage and redox cell signaling derangement Kazimierz S. Kasprzak 17. Copper ion regulation of gene expressions in yeast Laran T. Jensen and Dennis R. Winge 18. Toxic and essential metals in cellular response to signals James Koropatnick and Rudolfs K. Zalups Aschner, Wake Forest University School of Medicine, USA, Nazzareno Ballatori, University of Rochester School Of Medicine, USA, M.H. Bhattacharyya, Centre for Mechanistic Biology, USA, Gregory S. Buzard, Frederick Cancer Research and Development Centre, USA, Max Costa, New York University Medical Centre, USA, Gary L. Diamond, Syracuse Research Corporation, USA, Michael DiDonato, The Hospital for Sick Children, Toronto, Canada, Beth A. Hart, University of Vermont College of Medicine, USA, Sheila M. Healy, University of Arizona, USA, Laran T. Jensen, University of Utah Health Sciences Centre, USA, Margaret M. Jonah, Dominican University, USA, Kazimierz S. Kasprzak, Frederick Cancer Research and Development Centre, USA, Laura E. Kerper, University of Rochester School Of Medicine and Dentistry, USA, James Koropatnick, London Regional Cancer Centre, Ontario, Canada, Lawrence H. Lash, Wayne State University School of Medicine, USA, Raul Perez-Olle, National Cancer Institute at NIEHS, USA, Anthony Presta, University of Western Ontario, Canada, S.S. Rajan, Centre for Mechanistic Biology, USA, Christopher Rensing, Wayne State University School of Medicine, USA, Barry P. Rosen, Wayne State University School of Medicine, USA, Bibudhendra Sarkar, University of Toronto, Canada, Timothy J. Shafer, US Environmental Protection Agency, USA Martin J. Stillman, University of Western Ontario, Canada, Douglas M. Templeton, University of Toronto, Ca
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