Protein Phosphorylation in Cell Growth Regulation

About this book

Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the elk kinases and cyclings in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation. The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth.

Contents

Receptor and non-receptor tyrosine kinases; protein tyrosine phosphatases in cell growth regulation; role of JAK tyrosine in cytokine signal transduction; mitogen-activated kinases and the control of cell growth; role of the protein kinase C family in the regulation of gene expression; phosphorylation of transcription factors and chromatin-associated proteins; regulation of the NF-KE family of transcriptions factors by protein phosphorylation; regulation of components in the translational machinery by protein phosphorylation; structure and function of the interferon-induced protein kinase PKR and related enzymes; protein kinase and phosphatases in cell cycle control.

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