Books  Animal & General Biology  Biochemistry & Molecular Biology 

Receptor Activation by Antigens, Cytokines, and Growth Factors

Series: Annals of the New York Academy of Sciences

Edited By: David Naor

New York Academy of Sciences

Hardback | Dec 1995 | #51501 | ISBN: 0897669517
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About this book

Upon ligand binding, cell-surface receptors transmit activity signals into the cell, activating multiple metabolic and mitogenic pathways. Although the nature of the stimulatory molecules is infinitely varied, the principles involved in propagating the signals are ubiquitous. Thus, such different stimulators as antigens, cytokines, hormones, and growth factors use similar transduction principles, including ligand-induced receptor internalisation of receptor-ligand complexes, activation of G proteins, aligomerisation, increases in Ca2+ uptake, activation of tyrosine kinases or other kinases and phosphatases, protein phosphorylation or dephosphorylation, and the triggering of oncogenes and transcription factors. The signalling molecules interact with each other through universal "zippers", such as SH2 and SH3 domains. This volume integrates the work of the most significant contributors to the field in elucidating the mechanisms involved in these signal transduction pathways.


Receptor Structures and Signalling Mechanisms Common to Multiple Biological Systems; Cell Receptors of the Immune System - Development, Structure, Function and Diversity; Signal Transduction and Second Messengers in Activated Cells of the Immune System; Cytokine Receptors; Growth Factor and Hormone Receptors - Structure and Function.

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