Books  Animal & General Biology  Biochemistry & Molecular Biology 

Regulation of Alternative Splicing

Series: Progress in Molecular and Subcellular Biology Volume: 31

Edited By: P Jeanteur

230 pages, 26 figs, 5 tabs


Hardback | Dec 2002 | #136490 | ISBN: 3540438335
Availability: Usually dispatched within 1 week Details
NHBS Price: £198.00 $255/€217 approx

About this book

The generality and quantitative extent of alternative splicing have only now begun to be fully appreciated. The first draft of the complete human genome led to the surprisingly low figure of about 32,000 genes. The extensive use of alternative splicing and its consequences in terms of coding capacity could account for this discrepancy and help fill the complexity gap between the genome and the proteome. After a computer-based assessment of the frequency of alternative splicing, this book addresses mechanistic aspects followed by examples of its involvement in important cellular processes. Finally, it raises the possibility of artificial modulation of alternative splicing by antisense nucleotides.


Prediction and Statistical Analysis of Alternatively Spliced Exons * Multiple Roles of the SR Protein Family in Splicing Regulation * Heterogeneous Nuclear Ribonucleoprotein Particle A/B Proteins and the Control of Alternative Splicing of the Mammalian Heterogeneous Nuclear Ribonucleoprotein Particle A1 pre-mRNA * Phosphorylation-Dependent Control of the Pre-mRNA Splicing Machinery * Splicing Regulation in Drosophila Sex Determination * Alternative Pre-mRNA Splicing and Regulation of Programmed Cell Death * Alternative Pre-mRNA Splicing and Neuronal Function * Modulation of Alternative Splicing by Antisense Oligonucleotides.

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