How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. This book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Mullerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.
First published in 1995.
1. Historical landmarks in studies of reproduction and sex determination; 2. Mechanisms of sex determination; 3. Differentiation of the gonads; 4. Differentiation of the genital duct system; 5. Anomalous sexual development in domestic species; 6. Abnormal sexual development in laboratory rodents; 7. Abnormal sexual development in man; 8. Sexual differentiation in chimaeras; 9. Asymmetries in the reproductive system and their significance; 10. Concluding thoughts and a current perspective.
'! a pleasure to read because of Hunter's clear style ! a successful amalgamation of information from many mammalian species ! a concise and well-written summary of what is known and hypothesized about mammalian sex determination and differentiation !' Science '! eminently suitable for the advanced students for whom it is intended and is a must for anyone involved in the field of mammalian sex differentiation.' Nature '! elegant and informative ! it fully deserves a place on the shelves of all university libraries and in departments and units with any interest in reproduction and development.' Journal of Anatomy '! a sound contribution to a fascinating, much debated, and currently widely investigated field ! a really exciting monograph.' Animal Reproduction Science