Books  Animal & General Biology  Biochemistry & Molecular Biology 

Signal Transduction


Series: Modular Texts in Molecular and Cell Biology Series Volume: 1

Edited By: Carl-Henrik Heldin and Mary Purton

365 pages, 2 col & 3 b/w illus, 104 figs, tabs

Chapman & Hall

Paperback | Dec 1996 | #52808 | ISBN: 0748740740
Availability: Usually dispatched within 6 days Details
NHBS Price: £38.00 $49/€42 approx

About this book

Written for a readership with a basic understanding of molecular and cell biology, and intended for graduate students and researchers, this text provides an overview of signal transduction. Common themes and structures are emphasized, and there are extensive cross-references between chapters. In a series of 23 short chapters, researchers provide reviews of topics ranging from cell-membrane receptors to gene regulation. The major classes of cell-surface receptors are described, and knowledge of the molecules and pathways important for cytoplasmic signal transduction are summarized. Responses within the nucleus are also reviewed.


Part 1 Cell Surface Receptors. 1. Signaling through receptor tyrosine kinses. 2. Singal transduction through class I receptors. 3. Signaling though cytokine class II receptors. 4. Singaling though hematopoietic antigen receptors. 5. Signaling though protein serine/threonine kinase receptors. 6. Singaling though members of the tumor necrosis. 7. Signaling through G-protein-coupled receptors. 8. Receptor-mediated endocytosis of growth factors. Part 2 Cytoplasmic Signal Transduction. 9. SH2, SH3 and PH domains. 10. Ras signaling. 11. MAP kinases in multiple signaling transduction. 12. Function of phospholipases in signal transduction. 13. Multiple roles for phosphoinositide 3-kinases in signal transduction. 14. Calcium signaling. 15. Cyclic AMP and cyclic GMP in cell signaling. 16. The protein kinase C egen family. 17. Protein tyrosine phosphates. 18. Protein serine/threonine phosphatases. 19. G proteins in signal transduction. Part 3 Nuclear Reponses. 20. Steroid hormone and nuclear receptors. 21. Transcription factors. 22. The p53 tumor suppressor. 23. Cell cycle regulation.

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