Books  Animal & General Biology  Genetics 

Signals, Switches, Regulons, and Cascades: Control of Bacterial Gene Expression


Series: Society for General Microbiology Symposium Volumes

Edited By: Christopher Thomas and David Hodgson

350 pages, 5 b/w illus, 50 figs, 25 tabs

Cambridge University Press

Hardback | Apr 2002 | #129820 | ISBN: 0521813883
Availability: Usually dispatched within 6 days Details
NHBS Price: £83.99 $108/€92 approx

About this book

DNA sequencing has provided a wealth of information on the genetic material stored in bacterial genomes. The use of DNA arrays and proteomics will transform the scale of our ability to describe the patterns of gene expression as bacteria respond to their environments. However, the ability to control bacteria in a clinical context or exploit them in industrial or environmental contexts also depends on understanding the regulatory mechanisms which connect input experience to output response at the genetic level. This book deals with our current knowledge of the circuits and networks that govern bacterial gene expression - from the single gene to the whole genome - and which provide the framework for explaining the data from the post genomics revolution.

...well written and illustrated... Quarterly Review of Biology


Editor's preface; 1. Microbial reaction to environment: bacterial stress responses revisited in the genomic-proteomic era F. C. Neidhardt; 2. Gene variation and gene regulation in bacterial pathogenesis D. Hood and R. Moxon; 3. DNA topology and regulation of bacterial gene expression C. J. Dorman; DNA rearrangements and regulation of gene expression I. C. Blomfield; 4. Structures of multisubunit DNA-dependent RNA polymerases R. D. Finn, E. V. Orlova, M. van Heel and M. Buck; 5. The ECF sigma factors of Streptomyces coelicolor A3(2) M. S. B. Paget, H-J. Hong, M. Bibb and M. J. Buttner; 6. Secrets of bacterial transcription initiation taught by the Escherichia coli FNR protein D. Browning, D. Lee, J. Green and S. Busby; 7. What can be learned from the LacR family of Escherichia coli? B. Muller-Hill; 8. Regulation of the L-arabinose operon in Escherichia coli R. Schleif; 9. Transcription termination control in bacteria T. M. Henkin; 10. Antisense RNAs in programmed cell death K. Gerdes; 11. Control of signal transduction in the sporulation phosphorelay J. A. Hoch; 12. A stranglehold on a transcriptional activator by its partner regulatory protein - the case of the NifL-NifA two-component regulatory system R. Dixon; 13. Is anybody here? Cooperative bacterial gene regulation via peptide signals between Gram-positive bacteria D. A. Morrison; 14. Quorum sensing in Gram-negative bacteria: global regulons controlled by cell-density-dependent chemical signalling N. A. Whitehead, A. K. P. Harris, P. Williams and G. P. C. Salmond; Index.

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David A. Hodgson is a Reader in Microbiology in the Department of Biological Sciences at the University of Warwick. Christopher M. Thomas is Professor of Molecular Genetics in the School of Biological Sciences at the University of Birmingham.

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