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Solving Problems with NMR Spectroscopy presents the basic principles and applications of NMR spectroscopy with only as much math as is necessary. It shows how to solve chemical structures with NMR by giving clear examples and solutions. This text will enable organic chemistry students to choose the most appropriate NMR techniques to solve specific structures. The problems to work and the discussion of their solutions and interpretations will help readers become proficient in the application of important, modern 1D and 2D NMR techniques to structural studies. This book presents the most important NMR techniques for structural determinations; offers a unique problem-solving approach; uses questions and problems, including discussions of their solutions and interpretations, to help readers grasp NMR; and, avoids extensive mathematical formulas. It contains Forewords by Nobel Prize winner Richard R. Ernst and Lloyd M. Jackman.
The Basics of Modern NMR Spectroscopy:What is NMR? Instrumentation. Creating NMR Signals. Spin-Echo and Polarization Transfer: Spin-Echo Formation in Homonuclear and Heteronuclear Systems. Cross-Polarization. Polarization Transfer in Reverse. The Second Dimension: Data Acquisition in 2D NMR. Data Processing in 2D NMR. Plotting 2D Spectra. Nuclear Overhauser Effect: nOe and Selective Population Transfer. Relaxation. Mechanism of nOe. Factors Affecting nOe. Some Practical Hints. Important 2D NMR Experiments: Homo- and Heteronuclear J-Resolved Spectroscopy. Homonuclear and Heteronuclear Shift-Correlation Spectroscopy. Two-Dimensional Nuclear Overhauser Spectroscopy. Two-Dimensional Chemical Exchange Spectroscopy. Homonuclear Hartmann-Hahn Spectroscopy (HOHAHA), or Total Correlation Spectroscopy (TOCSY). Inverse NMR Spectroscopy. Inadequate. The Third Dimension: Basic Philosophy. Types and Positions of Peaks in 3D Spectra. Recent Developments in NMR Spectroscopy: Selective Pulses in Modern NMR Spectroscopy. One-Dimensional Experiments Using Soft Pulses. Heteronuclear Selective 1D NMR Experiments. Two-Dimensional Experiments Using Soft Pulses. Soft Excitation in Two Dimensions. Three-Dimensional Experiments Using Soft Pulses. Field Gradients. Logical Protocol for Solving Complex Structural Problems: 3-Hydroxylupanine. (1). (+)-Buxalongifolamidine. (2). References. Subject Index.
Solving Problems with NMR Spectroscopy is a very welcome addition to the existing literature. It fulfills a real need for an up-to-date and authoritatively written introduction for students and practitioners of NMR. --RICHARD R. ERNST, Nobel Prize in Chemistry, 1991
