Series: Very Short Introduction Series (VSI) Volume: 303
144 pages, 15 b/w illustrations
The topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'.
In this "Very Short Introduction", Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation.
Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future.
1: Orientation to stem cells
2: Embryonic stem cells
3: Personalised pluripotent stem cells
4: Proposed therapies using pluripotent stem cells
5: Tissue-specific stem cells
6: Current therapy with tissue specific stem cells
7: Realistic and unrealistic expectations
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Jonathan Slack is Director of the Stem Cell Institute at the University of Minnesota, USA, and also holds the Tulloch Chair of Stem Cell Biology. His recent research has focused on the mechanisms of regeneration of missing parts, and on methods for inducing the transformation of one tissue type into another by overexpression of specific genes. He has a particular interest in attempting to reprogram other tissue types into pancreatic beta cells, which could be used for the treatment of some types of diabetes. He has published over 180 research and review papers in scientific journals, and has also written three books, including Essential Developmental Biology (2012), an undergraduate textbook.