The Chemical Biology of DNA Damage

About this book

A modern reference on a key topic in biochemical toxicology that reaches out into molecular biology, molecular medicine and environmental science, this book covers basic concepts as well as the analysis and prediction of genotoxicity at the molecular level.

Contents

CHEMISTRY AND BIOLOGY OF DNA LESIONS Chemical biology of DNA adducts: Origins, formation and impact Inflammation and DNA damage Chemical pathways of oxidative DNA damage by reactive oxygen species DNA adducts from lipid oxidation Polycyclic aromatic hydrocarbons: Multiple pathways of formation of DNA lesions Heterocyclic aromatic amines as food mutagens The genotoxic endogenous and exogenous estrogen pathway and DNA damage UNDERSTANDING STRUCTURE-FUNCTION RELATIONSHIPS AND BIOLOGICAL ACTIVITY Overview NMR solution structures of small DNA lesions Structures of bulky lesions from NMR studies DNA base sequence effects on structures of aromatic amine-guanine adducts in solution Insight into base excision repair of oxidative lesions Structure-function relationships in nucleotide excision repair Transcription and transcription-coupled repair X-ray crystallographic studies of DNA lesions in polymerases Modeling polymerases containing DNA lesions at their active sites Bulky DNA lesions for probing polymerase switching phenomena in translesion DNA replication

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Biography

Nicholas E. Geacintov is Professor of Chemistry and currently the Chair of the Department of Chemistry at New York University. Suse Broyde is Professor of Biology and Affiliate Professor of Chemistry at New York University.