Books  Animal & General Biology  General Biology 

The Synapse

By: Morgan Sheng(Editor), Bernardo Sabatini(Editor), Thomas C Südhof(Editor)

300 pages, illustrations

Cold Spring Harbor Laboratory Press

Hardback | Jul 2012 | #201456 | ISBN-13: 9781936113026
Availability: Usually dispatched within 6 days Details
NHBS Price: £106.00 $136/€115 approx

About this book

Synapses are bulbous structures where two neurons communicate. Neurotransmitter molecules released from the pre-synaptic terminal of one neuron diffuse to the post-synaptic terminal on the other, binding to receptors that lead to propagation or modulation of the signal.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the highly complex structures of the pre- and post-synaptic regions, as well as the trafficking mechanisms that transport vesicles containing neurotransmitters. The contributors discuss how long-term potentiation (LTP) and depression (LTD) in signal transmission form the basis of learning and memory. The roles of calcium signaling in regulating synaptic and cell function, and techniques to study such signaling events, are also covered.

This volume also includes discussions of synaptic dysfunction in disorders such as autism and Alzheimer disease. It is an indispensable reference for neurobiologists, cell and developmental biologists, and anyone wishing to understand how the basic building blocks of the brain are put together and communicate.



Ultrastructure of Synapses in the Mammalian Brain
    Kristen M. Harris and Richard J. Weinberg
Synaptic Cell Adhesion
    Markus Missler, Thomas C. Südhof, and Thomas Biederer
Synaptic Vesicle Exocytosis
    Thomas C. Südhof and Josep Rizo
Calcium Control of Neurotransmitter Release
    Thomas C. Südhof
Synaptic Vesicle Endocytosis
    Yasunori Saheki and Pietro De Camilli
Synaptic Vesicle Pools and Dynamics
    AbdulRasheed A. Alabi and Richard W. Tsien
Short-Term Presynaptic Plasticity
    Wade G. Regehr
Vesicular and Plasma Membrane Transporters for Neurotransmitters
    Randy D. Blakely and Robert H. Edwards
The Postsynaptic Organization of Synapses
    Morgan Sheng and Eunjoon Kim
Synaptic Neurotransmitter-Gated Receptors
    Trevor G. Smart and Pierre Paoletti
Studying Signal Transduction in Single Dendritic Spines
    Ryohei Yasuda
Calcium Signaling in Dendritic Spines
    Michael J. Higley and Bernardo L. Sabatini
NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depresssion (LTP/LTD)
    Christian Lüscher and Robert C. Malenka
Presynaptic LTP and LTD of Excitatory and Inhibitory Synapses
    Pablo E. Castillo
Homeostatic Synaptic Plasticity: Local And Global Mechanisms For Stabilizing Neuronal Function
    Gina Turrigiano
Neuronal Activity–Regulated Gene Transcription in Synapse Development and Cognitive Function
    Anne E. West and Michael E. Greenberg
Synapses and Memory Storage
    Mark Mayford, Steven A. Siegelbaum, and Eric R. Kandel
Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities
    Huda Y. Zoghbi and Mark F. Bear
Synapses and Alzheimer’s Disease
    Morgan Sheng, Bernardo Sabatini, and Thomas C. Südhof


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