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The Ubiquitin-Proteasome Proteolytic System: From Classical Biochemistry to Human Diseases

Series: Recent Advances in Human Biology Volume: 9

Edited By: Aaron J Ciechanover and Maria G Masucci

240 pages, B/w photos, figs, tabs

World Scientific Publishing

Hardback | Jan 2003 | #136099 | ISBN: 9812381007
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NHBS Price: £55.99 $72/€61 approx

About this book

Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes. This volume presents an up-to-date overview of the ubiquitin system.


The ubiquitin system and some of its roles in cell cycle control, A. Hershko; the ubiquitin system and the N-end rule, A. Varshavsky; phosphorylation-dependent substrate recognition in ubiquitin-mediated proteolysis, M. Tyers et al; the 26S proteosome - a supramolecular assembly designed for controlled proteolysis, W. Baumeister and P. Zwickl; mechanisms and regulation of ubiquitin-mediated, limited processing of the NF-kappaBalpha precursor protein p105, A. Ciechanover et al; regulation of receptor tyrosine kinases by ubiquitination, A. Citri and Y. Yarden; regulation of p27 degradation, J. Bloom and M. Pagano; ubiquitin-system-dependent regulation of growth hormone receptor signal transduction and effects of oxidative stress, C.M. Alves dos Santos and G.J. Strous; inhibition of the ubiquitin-proteosome system by a viral repetitive sequence, N.P. Dantuma and M.G. Masucci; autosomal recessive juvenile Parkinsonisms and the ubiquitin pathway, K. Tanaka et al.

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