Combinational Chemistry A Practical Approach

About this book

Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.

Contents

Synthesis of combinatorial libraries using the portioning-mixing procedure; One-bead-one-compound combinatorial library method; Synthesis and screening of positional scanning synthetic combinatorial libraries; High throughput combinatorial synthesis of discrete compounds in multimilligram quantities; Positionally addressable parallel synthesis on membrane supports; Resins and anchors for solid phase organic synthesis; Organic reactions on solid support - an overview; Analytical methods in combinatorial chemistry; Multi-component reactions (mcrs) of isocyanides and their chemical libraries; Multi-step solution phase combinatorial synthesis; Experimental techniques in fluorous synthesis; Dendrimer-supported combinatorial chemistry; Automated solution phase synthesis and its application in combinatorial chemistry; Combinatorial discovery and optimization of electrocatalysts; Combinatorial library synthesis using polymer-supported catalysts; Combinatorial Approaches to chiral catalysts discovery

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