Introduction to Protein Architecture: The Structural Biology of Proteins

About this book

Explains the general characteristics that underlie the very great variety of structures, functions and interactions of proteins observed in nature.

Contents

CHAPTER 1: THE PHOTOSYNTHETIC REACTION CENTRE: PROTEIN STRUCTURE IN A MICROCOSM; The reaction centre from Rhodopseudomonas viridis; Conclusions; Recommended reading and references; Exercises and problems; CHAPTER 2: IN VIVO, IN VITRO, IN SILICO; Why study proteins?; Protein structure and conformation; The known protein sequences; The protein data bank; The World-Wide Web; Summary; Glossary; Useful Web sites; Recommended reading and references; Exercises, problems and weblems; CHAPTER 3: PATTERN AND FORM IN PROTEIN STRUCTURE; Helices and sheets; The heirarchical nature of protein architecture; An album of small structures; Classification of protein structures; Loops; Protein-ligand interactions; Useful Web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 4: THE VARIETIES OF PROTEIN STRUCTURE; Catalogues of protein structure; The known structures; alpha-helical proteins; beta-sheet proteins; alpha + beta proteins; alpha/beta proteins; Closed beta-alpha-beta barrel structures; Irregular structures; Conclusions; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 5: MOLECULAR EVOLUTION; Evolution of protein structures; Structural relationships among related molecules; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 6: EVOLUTION IN SELECTED PROTEIN FAMILIES; Evolution of the globins; Evolution of serine proteinases of the chymotrypsin family; NAD-binding domains of dehydrogenases; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 7: SOME PROTEINS OF THE IMMMUNE SYSTEM; Antibody structure; Proteins of the Major Histocompatibility Complex; T cell receptors; Useful web sites; Recommended reading and references; Exercises, problems, and weblems; CHAPTER 8: CONFORMATIONAL CHANGES IN PROTEINS; Structural changes arising from change in state of ligation; Hinge motions in proteins; The helix interface shear mechanism of conformational change; The allosteric change in haemoglobin; Serpins: SERine Proteinase Inhibitors; Higher-level structural changes; INDEX

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