299 pages, Col plates, figs, tabs
A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care & husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.
provides a major source of information on the mouse as an experimental model, and can be used as a detailed manual for researchers ... offers tried-and-tested protocols, with handy trouble-shooting tips and other supporting advice. It is aimed for both scientists new to the field and those who want an overview of the latest techniques. Index at the end of the book facilitates quick orientation and selective reading. Croatian Medical Journal (CMJ) We give a thumbs up to a book already well thumbed and in use in the lab. The Genetical Society of Great Britain
Hetherington, Doe and Hay, mouse care and husbandry; Glenister and Rall, cryopreservation and rederivation of embryos and gametes; Nonchev and Maconochie, spatial analysis of gene expression; Maine, mapping phenotypic trait loci; Denny and Brown, mapping genomes; Akeson et al, mouse cytogenetics and FISH; Eppig, electronic tools for accessing the mouse genome; Justice, mutagenesis of the mouse germline; Hammes and Schedl, generation of transgenic mice from plasmids, BACs and YACS; Plagge, Kelsey and Allen, directed mutagenesis in embryonic stem cells.
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