282 pages, illus
Helps the reader get started in creating phylogenetic trees from protein or nucleic acid sequence data. Although aimed at molecular and cell biologists, it also serves students who may be familiar with phylogenetic theory but are unfamiliar with the tools used to apply that theory. The reader is led through identifying sequences that are homologous to a sequence of interest, downloading these sequences from databases, creating multiple alignments, and using several different methods to construct trees.
Reflecting new software updates, and with more advanced topics, the Fourth Edition helps the student create phylogenetic trees from protein or nucleic acid sequence data. The reader is taken step-by-step from identifying the sequences required, to drawing the tree for presentation to an intended audience.
Read Me First
Tutorial: Estimate a Tree
Acquiring the Sequences
Aligning the Sequences
Major Methods for Estimating Phylogenetic Trees
Drawing Phylogenetic Trees
Bayesian Inference of Trees with MrBayes
Working with Various Computer Platforms
Advanced Alignment with GUIDANCE
Reconstructing Ancestral Sequences
Detecting Adaptive Evolution
Learn to Program
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BARRY G. HALL is Director of the Bellingham Research Institute, Adjunct Professor of Genomics and Bioinformatics at the Allegheny-Singer Research Institute's Center for Genomic Sciences, and Professor Emeritus of Biology, University of Rochester, USA. He was a founding member of the Society for Molecular Biology and Evolution and has been Editor-in-Chief of the journal Molecular Biology and Evolution, and on the Editorial Boards of Genetica, the Journal of Molecular Evolution, and the Journal of Bacteriology.