410 pages, colour illus.
An advanced undergraduate textbook focusing on the molecules and mechanisms which underlie the developmental process. In recent years, the genetic and molecular mechanisms underlying cellular behaviour have begun to be elucidated. Taking advantage of this new knowledge, Martinez Arias and Stewart here present developmental biology from a new standpoint: one in which the molecules and the genes that encode them, rather than the organisms, take centre stage. This is a compelling modern way of looking at developmental biology. Starting with the genetic programs that underlie development and working up allows a better understanding of the logic of development. TEACHING AIDS Online Resource Centre: www.oup.com/uk/best.textbooks/biochemistry/martinez/ Includes sample chapter, and all illustrations available free to download
1. Introduction: towards a molecular basis of development; 2. Programs and regulatory elements in DNA and RNA; 3. Decoding the program: transcription; 4. Cell surface proteins: receptors, ligands, and their environment; 5. Intracellular effectors of cell interactions: signalling pathways and networks; 6. Cells and their interactions; 7. Basic cellular routines: division, differentiation, and death; 8. The generation of lineages: a developmental routine; 9. Long- and short-range influences in the generation of cell diversity; 10. Cell type specification: a developmental operation; 11. Patterns in 'one' and two dimensions; 12. Patterns in three dimensions
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