United States
£ GBP
Elaborates the key concepts of molecular biology: DNA transcription, translation, replication, and repair. Experimental methods are extensively covered. The text presumes a prior course in general genetics.
Part 1. Introduction. 1. A Brief History. 2. The Molecular Nature of Genes. 3. An Introduction to Gene Function. Part 2. Methods in Molecular Biology. 4. Molecular Cloning Methods. 5. Molecular Tools for Studying Genes and Gene Activity. Part 3. Transcription in Prokaryotes. 6. The Transcription Apparatus of Prokaryotes. 7. Operons: Fine Control of Prokaryotic Transcription. 8. Major Shifts in Prokaryotic Transcription. 9. DNA-Protein Interactions in Prokaryotes. Part 4. Transcription in Eukaryotes. 10. Eukaryotic RNA Polymerases and their Promoters. 11. General Transcription Factors in Eukaryotes. 12. Transcription Activators in Eukaryotes. 13. Chromatin Structure and Its Effects on Transcription. Part 5. Posttranscriptional Events. 14. Posttranscriptional Events I: Splicing. 15. Posttranscriptional Events II: Capping and Polyadenylation. 16. Posttranscriptional Events III: Other Events. Part 6. Translation. 17. The Mechanism of Translation I: Initiation. 18. The Mechanism of Translation II: Elongation and Termination. 19. Ribosomes and Transfer RNA. Part 7. DNA Replication, Recombination and Transposition. 20. DNA Replication I: Basic Mechanism and Enzymology. 21. DNA Replication II: Detailed Mechanism. 22. Homologous Recombination. 23. Site-Specific Recombination and Transposition. Part 8. Genomes. 24. Genomics.
Received BS in Chemistry from The College of Wooster in 1964 Postdoctoral work at UC-San Francisco with William Rutter American Cancer Society Research Scholar for two years
