600 pages, illustrations
Updated throughout to reflect the latest discoveries in this fast-paced field, Essential Genetics: A Genomics Perspective, Sixth Edition, provides an accessible, student-friendly introduction to modern genetics. Designed for the shorter, less comprehensive course, the Sixth Edition presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. It goes on to discuss the development and progression of genetics as a field of study within a societal and historical context. The Sixth Edition includes new learning objectives within each chapter which helps students identify what they should know as a result of their studying and highlights the skills they should acquire through various practice problems.
What's new in the Sixth Edition?:
- Chapter 1 includes a new section on the origin of life
- Chapter 2 includes a revised discussion of the complementation test and how it is used to determine whether two mutations have defects in the same gene
- Chapter 3 incorporates new data showing that the folding of interphase chromatin into chromosome territories has the form of a fractal globule. It also includes a new section on progenitor cells and embryonic stem cells
- Chapter 4 includes a new section discussing how copy-number variation in human amylase evolved in response to increased dietary starch as well as the latest on hotspots of recombination
- Chapter 5 is updated with the latest information on hazards of polycarbonate food containers. It also includes a new section on the genetics of schizophrenia and autism spectrum disorder
- Chapter 6 includes a revised section on restriction mapping and also discusses the newest massively parallel DNA sequencing technologies that can yield the equivalent of 200 human genomes' worth of DNA sequence in a single sequencing run
- Chapter 7 has been updated with a shortened and streamlined discussion of recombination in bacteriophage
- Chapter 8 includes new discoveries concerning the mechanisms of intrinsic transcriptional termination as well as rho-dependent termination
- Chapter 9 is updated with a new section on stochastic effects on gene expression and an expanded discussion of the lactose operon. There is also a revised discussion of galactose gene regulation in yeast, as well as new sections on long noncoding RNAs
- Chapter 10 includes new sections on ancient DNA sequences of the Neandertal and Denisovan genomes
- Chapter 11 examines master control genes in development
- Chapter 12 includes a new section on the repair of double-stranded breaks in DNA by nonhomologous end joining or template-directed gap repair
- Chapter 13 has been extensively revised with the latest data on cancer.
- Chapter 14 includes a new section on the detection of natural selection, as well as a new section on conservation genetics
- Human Evolutionary Genetics integrated throughout the text.
Chapter 1 The Genetic Code of Genes and Genomes
Chapter 2 Transmission Genetics: Heritage from Mendel
Chapter 3 The Chromosomal Basis of Heredity
Chapter 4 Gene Linkage and Genetic Mapping
Chapter 5 Human Chromosomes and Chromosome Behavior
Chapter 6 DNA Structure, Replication, and Manipulation
Chapter 7 The Genetics of Bacteria and Their Viruses
Chapter 8 The Molecular Genetics of Gene Expression
Chapter 9 Molecular Mechanisms of Gene Regulation
Chapter 10 Geonomics, Proteomics, and Genetic Engineering
Chapter 11 The Genetic Control of Development
Chapter 12 Molecular Mechanisms of Mutation and DNA Repair
Chapter 13 Molecular Genetics of the Cell Cycle and Cancer
Chapter 14 Molecular Evolution and Population Genetics
Chapter 15 The Genetic Basics of Complex Inheritance
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Daniel L. Hartl is Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University. He has authored or coauthored more than 300 scientific articles and 20 books in genetics, genomics, molecular evolution, and population genetics. He has served as president of the Genetics Society of America and the Society for Molecular Biology and Evolution. He has also served as Chairman of his department at Harvard. He is was elected to the National Academy of Sciences and the American Academy of Arts and Sciences. He received his PhD from the University of Wisconsin. His research interests include evolutionary genomics, molecular evolution and population genetics.