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From Bench to Pilot Plant: Process Research in the Pharmaceutical Industry

Includes previously unpublished results on stages of scale up and product development

Series: ACS Symposium Series Volume: 817

By: Mehdi Nafissi (Editor), John A Ragan (Editor), Keith M DeVries (Editor)

172 pages, 4 b/w photos, 104 b/w illustrations

American Chemical Society

Hardback | Apr 2002 | #132008 | ISBN-13: 9780841237438
Availability: Usually dispatched within 6 days Details
NHBS Price: £74.99 $95/€89 approx

About this book

From Bench to Pilot Plant: Process Research in the Pharmaceutical Industry examines the bridges between research, product development and manufacturing. From Bench to Pilot Plant examines the transfer of small scale research results to a marketable product through stages of scale up and discusses how to alleviate the problems of high cost, environmental concerns and safety. Chapters include advances in technology of product development and transferring modern research methodologies to scale up and manufacturing.

"The presentation is excellent with well drawn diagrams and will form an excellent addition to any library and indeed complement many others in the field of process research in the pharmaceutical industry."
- Current Engineering Practice


Contents

1: The Anatomy of Process Research and Development
2: Design and Development of a Practical Process for Anti-MRSA Carbepenems
3: Synthesis of Steroid 'Antedrugs' for Evaluation as Safe Treatment for Asthma
4: Development of Catalytic Asymetric Micheal Addition in the Synthesis of the Endothelin Antagonist ABT-546
5: Creativity on Large Scale-Lesson from Scale-Up
6: Synthesis of RO 1130830, a Matrix Metalloproteinase Inhibitor: Evolution of a Research Scheme to Pilot Plant Production
7: Four Generations of Pyrrolopyrimidienes
8: Synthesis, Discovery and Separation of the Atropisomers of CP-465,022
9: Efficient, First Generation Synthesis of SERM 2


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