In "Protein Structure, Stability, and Folding", Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, "Protein Structure, Stability, and Folding" offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.
Both theoretical and experimental approaches for studying protein structure, stability, and folding are described in the book. The fundamental concepts are clearly presented. The topics on modeling and simulation would be useful for protein designers. The book starts with a concise overview on the fundamental thermodynamic concepts and governing forces for protein folding. - PHARMACEUTICAL RESEARCH "focuses on the structure-stability relationship and in the well-balanced mixture of experimental and theoretical chapters, all of which are written by experts in the fields." - Chembiochem
Stabilization of Protein Structure. Protein Stabilization by Naturally Occurring Osmolytes. The Thermodynamic Linkage Between Protein Structure, Stability, and Function. Measuring the Conformational Stability of a Protein by Hydrogen Exchange. Modeling the Native State Ensemble. Conformational Entropy in Protein Folding: A Guide to Estimating Conformational Entropy via Modeling and Computation. Turn Scanning: Experimental and Theoretical Approaches to the Role of Turns. Laser Temperature-Jump Methods for Studying Folding Dynamics. Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins. Molecular Dynamics Simulations of Protein Unfolding/Folding.
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