445 pages, 210 figs
Provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.
What better tribute to the late Joel Keizer than to expand his unfinished accounts of teaching and research to a splendid book. Computational Cell Biology performs much more than it promises, for it also deals with considerable analytical material and with aspects of molecular biology. There's something for everybody interested in how modeling leads to greater understanding in the core of the biological sciences. -Lee Segel (Weizmann Institute)
Preface * Dynamic Phenomena in Cells * Voltage Gated Ionic Currents *Transporters and Pumps * Fast and Slow time Scales* Whole Cell Models *Intercellular Communication * Spatial Modeling * Modeling Intracellular Calcium Waves and Sparks * Biochemical Oscillations *Cell Cycle Controls * Modeling the Stochastic Gating of Ion Channels *Molecular Motors: Theory * Molecular Motors: Examples * Numerical Algorithms * References * Index.
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