About this book
The end of the 20th century brought with it a revolution in molecular biology that culminated in advances such as the completion of the human genome. This has brought optimism to the fields of toxicology and environmental health, and the anticipation that molecular biomarkers might soon come of age and have a major impact on human and environmental health. Biomarker research is an area of current interest to scientists in a number of fields that are concerned with environmental exposure to pollutants and environmentally associated disease.Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives provides comprehensive coverage of the current status and future prospects of a field that will play a key role in emerging areas of public health and medicine. It focuses on the risk to human and environmental health of exposure to persistent organic pollutants, heavy metals, airborne toxics, environmental estrogens, and other environmental pollutants. This material will aid researchers in understanding, treating, and preventing environmentally induced disease. V alidated molecular biomarkers have long been recognized as invaluable tools for identifying and preventing human disease. As biomarkers begin to be applied more widely, it is also important to assure that they are implemented ethically, with attention to the social and legal issues associated with their use. Biomarkers of Environmentally Associated Disease is an outstanding resource providing state-of-the-art information for the fields that encompass molecular biomarkers.
Contents
OVERVIEWOverview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health, William A. Suk and Samuel H. WilsonEthical and Legal Considerations in Biological Markers Research, Richard Sharp and Paul ZigasScientific and Policy Issues Affecting the Future of Environmental Health Sciences, Bernard GoldsteinGENOMICS-BASED BIOMARKERS/GENETIC TOXICOLOGY BIOMARKERSEcogenetics: Genetic Susceptibility to Environmental Adversity, Dan NebertToxicogenomics and Pharmacogenomics: Basic Principles, Potential Applications, and Issues, Peter GuengerichIndividual Susceptibility to Exposures: A Role for Genetic Variation in DNA Repair Genes, Harvey W. MohrenweiserStudies of DNA Repair and Human Cancer: An Update, Marianne Berwick, et al.DNA Adducts as Biomarkers of DNA Damage in Lung Cancer, S. Vulmiri and John DiGiovanniTamoxifen-DNA Adducts: Biomarkers for Drug-Induced Endometrial Cancer, Shinya Shibutani, Naomi Suzuki, and Arthur GrollmanPolycyclic Aromatic Hydrocarbon DNA Adducts and Human Cancer, Mikhail F. Denissenko, Moon-Shong Tang, and Gerd P. PfeiferQuantitative PCR: A Sensitive Biomarker of Gene-Specific DNA Damage and Repair, Bennett Van Houten, Yiming Chen, Janine H. Santos, and Bhaskar S. MandavilliFidelity of DNA Synthesis as a Molecular Biomarker, Kandace WilliamsMutational Specificity of Environmental Carcinogens, Kathleen Dixon and Mario MedvedovicBIOMARKERS OF METAL METABOLISMLearning-Induced Modulation of Neural Cell Adhesion Polysialytion State as a Biomarker of Prior Inorganic Lead Exposure During the Early Postnatal Period, Keith J. Murphy, Helen C. Gallagher, and Ciaran ReganMolecular Biomarkers for Mercury, Thomas Clarkson and Nazzareno BallatoriValidity of Mercury Exposure Biomarkers, Philippe Grandjean, Poul J. Jorgensen, and Pal WeileUrinary Arsenic Species in Relation to Drinking Water, Toenail Arsenic Concentrations and Genetic Polymorphisms in GSTM1 in New Hampshire, Maragaret Karagas, Heather H. Nelson, Karl T. Kelsey, Steven Morris, Joel D. Blum, Tor D. Tosteson, Mark Carey,Xiufen Lu, and X. Chris LeMolecular Responses of Mammalian Cells to Nickel and Chromate Exposure, Max Costa, Konstantin Salnikow, Jessica E. Sutherland, Thomas Kluz, Wu Peng, and Moon-Shong TangChromium: Exposure, Toxicity and Biomonitoring Approaches Anthony ZhitkovichUsing Plankton Food Web Variables as Indicators for the Accumulation of Toxic Metals in Fish, Carol Folt, Celia Y. Chen, and Paul C. PickhardtORGAN & SYSTEMS BIOMARKERSValidation of Exposure and Risk Biomarkers: Aflatoxin as a Case Study, John Groopman, Peta E. Jackson, Paul Turner, Christopher P. Wild, and Thomas W. KenslerBiomarkers of Early Effect in the Study of Cancer Risk, Laura Gunn, Luoping Zhang, Matthew S. Forrest, Nina T. Holland, and Martyn T. SmithProteomics in Toxicology - An Experience with Gentamicin, Sandy Kennedy, M.D. Kelly, C. Moyses, R. Ames, and R. ParekhXenopus laevis Genomic Bioma
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