427 pages, Figs, tabs
Covers basic and applied problems in the emerging field of comparative functional genomics. Offers a comparative perspective on the state of the art and key principles of genome sequencing, expression, evolution, and phylogenetics in organelles, prokaryotes, model organisms, and humans. Provides a unique and thorough treatment of biological databases, analysis of the transcriptome and proteome, and the bioinformatic approaches for comparative genome analysis.
...an excellent addition to the field of comparative genomics. (ASM News, December 2004) "...will provide interesting reading and perspective to almost everyone involved in biological sciences." (Quarterly Review of Biology, March 2004) "...certainly deserves a place in institutional libraries...depth of material covered is right for the busy scientist...precise and detailed..." (Briefings in Functional Genomics & Proteomics, Vol 2(4), February 2004) "...this book gives an illuminating look at the study of genomes through their sequence..." (Human Genomics, January 2004) "...covers basic and applied problems in the emerging field of comparative functional genomics..." (Genetic Engineering News, Vol 23(14), 2003)
SECTION I: GENOME FEATURES. Preface. The Prokaryotic Genome. Eukaryotes. Organelles. SECTION II: METHODOLOGIES. Molecular Biology Techniques for Genomics. Biological Databases. Computatonal Methods for the Analysis of Genome Sequence Data. SECTION III: COMPARATIVE GENOMICS. Molecular Evolution. Molecular Phylogeny. Appendix I.
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Cecilia Saccone is Professor of Molecular Biology at the University of Bari as well as the chair of the National Research Council (CNR) in Bari, Italy. Graziano Pesole is a professor in the Department of Physiology and General Biochemistry at the University of Milan, Italy.