557 pages, illus
Ecogenetics can be defined as the study of genetic determinants that dictate susceptibility to environmentally-influenced adverse health effects. The explosion in new, high throughput techniques for identifying genetic variants, coupled with the realization that the majority of human diseases arise through a complex interplay of genetics and environment has led to remarkable growth and interest in the field of ecogenetics. The first section of this book covers fundamental aspects of ecogenetic, such as history of the discipline, a discussion of the molecular tools currently available to assess genotypes and their pros and cons, the use of such measurements in molecular epidemiology studies, and considerations on how knowledge acquired in pharmacogenetics can be applied to ecogenetics. The second section discusses key genetic polymorphisms relevant for ecogenetics. The third section presents a disease-based approach, to address the question of how genetic polymorphisms can influence gene-environment interactions relevant to determining susceptibility to the disease. These core chapterss address various types of cancers, neurodegenerative diseases, cardiovascular disease, diabetes and obesity.
...a must-have for all toxicology and pharmacology students as well as a great resource for researchers and physicians. (Environmental Health Perspectives, June 2006) "...a vital in-office reference for any scientific researcher dedicated to the study of genetics...invaluable to public health researchers who are look at how global threats live Avian Flu might spread to the general populous...an indispensable reference to all health science libraries." (The Electric Review, March/April 2006)
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