450 pages, 68 Illus, 15 tabs
The fission yeast Schizosaccharomyces pombe is the favoured tool of many productive research groups throughout the world, serving as a useful model for fundamental principles and mechanisms, such as genome organization, differential gene regulation, cell-cycle control, signal transduction, or cellular morphogenesis. This book collates the current state of knowledge derived from molecular studies in this simple eukaryotic microorganism. The entire sequence of its genome has been completed, emphasizing the comparative value and model status of this yeast. The individual chapters, highlighting up-to-date views on prominent aspects of molecular organization, were written by active research scientists, presenting the results of their investigations to other workers in neighbouring fields.This book intends to serve the fission yeast community as a handy source of reference for years to come. It will also be of particular value to the ever-increasing number of researchers starting to look into fission yeast affairs for comparative reasons from other platforms of molecular genetics and cell biology.
From the Contents:Fission Yeast in General Genetics.- The Genome and Beyond.- Protein Kinases Driving the Cell Cycle.- Checkpoint Controls Halting the Cell Cycle.- Stress Responses in S. pombe.- DNA Replication in S. pombe.- DNA Repair Pathways.- The Retrotransposons of S. pombe.- Mating-type Cassettes: Structure, Switching and Silencing.- Centromere and Kinetochore Structure and Function.- Chromosome Cohesion and Segregation.- Telomere Organization and Nuclear Movements.- The Mitotic Spindle and Genome Segregation.- The Fission Yeast Actomyosin Cytoskeleton.- Regulation of Cytokinesis.- Control of Cell Polarity and Morphogenesis in Fission Yeast.- Cell Wall Synthesis.- Mating-type Control and Differentiation.- Initiation of Meiosis.- Control of Late Meiosis and Ascospore Formation.- RNA Polymerases and Accessory Factors.- Core Promoters in S. pombe: TATA and HomolD Boxes.- Mechanism and Control of pre-mRNA Splicing.- Transcription Termination.- Ubiquitin-dependent Proteolysis by the Proteasome.
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