Books  Animal & General Biology  Biochemistry & Molecular Biology 

Protein Phosphatases

Series: Topics in Current Genetics Volume: 5

Edited By: J Arino and DR Alexander

378 pages, 43 illus

Springer-Verlag

Hardback | Dec 2004 | #150349 | ISBN: 3540205608
Availability: Usually dispatched within 1-2 weeks Details
NHBS Price: £274.50 $346/€322 approx

About this book

This book provides an up-to-date and comprehensive overview of protein phosphatase research, a rapidly evolving field with increasing importance in our understanding of the molecular basis of cell biology and of pathological processes. The book covers dephosphorylation processes involving serine/threonine, as well as tyrosine and histidine residues, and aims to be a useful resource for both the advanced reader as well as the newcomer to the field. It is also valuable for those working in the pharmaceutical and Biotech industries.


Contents

Overview of Protein Serine/Threonine Phosphatases * Protein Phosphatase 1 * Protein Phosphatase 2A: A Multifunctional Regulator of Cell Signaling * Calcineurin: Roles of the Ca2+/Calmodulin-dependent Protein Phosphatase in Diverse Eukaryotes * Roles of Mammalian Protein Phosphatase 2C Family Members in the Regulation of Cellular Functions * PP5: the TPR Phosphatase * Protein Histidine Phosphatases in Signal Transduction and Metabolism * Anchoring of Protein Kinase and Phosphatase Signaling Units * Functional Proteomics in Phosphatase Research * Structure and Function of the T-cell Protein Tyrosine Phosphatase * Protein Tyrosine Phosphatase-based Therapeutics: Lessons From PTP1B * The CD45 Phosphotyrosine Phosphatase * Receptor Protein Tyrosine Phosphatases * The Shp-2 Tyrosine Phosphatase * SHP-1 Twelve Years on: Structure, Ligands, Substrates and Biological Roles * The Dual-specific Protein Tyrosine Phosphatase Family * Tyrosine Phosphatases in Cancer: Targets for Therapeutic Intervention.

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