Handbook of Industrial Mycology

About this book

Several excellent books have been published that address one or more aspects of the diverse field of industrial mycology, but none of them cover the entire process of fungal bioactive metabolites discovery. Until now. "The Handbook of Industrial Mycology" provides, in one volume, an overview of recent developments in industrial mycology with emphasis on the discovery of bioactive metabolites and, most importantly, their underlying biology and genetics. Two additional features distinguish this book from other books in the field: most chapters are prepared using experimental data to illustrate theories; and the authors provide methodologies and experimental protocols in their chapters. Presenting a comprehensive overview of recent advances, the book provides a framework of basic methods, tools, and organizational principles for channeling fungal germplasm into the academic, pharmaceutical, and enzyme discovery laboratories. It covers the complex range of processes involved in the discovery, characterization, and profiling of bioactive fungal metabolites. The book includes examples of several recently marketed fungal metabolites and explores the impact of fungi on applications in the pharmaceutical, food and beverage, agricultural, and agrochemical industries.

Contents

MYCOLOGY, INDUSTRIAL MYCOLOGY, AND FUNGAL BIOLOGY Industrial Mycology: Past, Present and Future Phylogeny of the Fungal Kingdom and Fungal-like Eukaryotes Biological Activities of Fungal Metabolites Cell Cycle Regulation in Morphogenesis and Development of Fungi Agrobacterium-Mediated Transformation of Filamentous Fungi FUNGAL SECONDARY METABOLITES DISCOVERY Fungal Germplasm for Drug Discovery and Industrial Applications Expression of Cosmid-Size DNA of Slow-Growing Fungi in Aspergillus nidulans for Secondary Metabolite Screening The Isolation and Structure Elucidation of Fungal Metabolites PCR-Based Data and Secondary Metabolites as Chemotaxonomical Markers in High Throughput Screening for Bioactive Compounds from Fungi Screening for Biological Activities in Fungal Extracts Sordarins, Inhibitors of Fungal Elongation Factor 2 BIOSYNTHESIS OF FUNGAL SECONDARY METABOLITES Secondary Metabolite Gene Clusters The Aflatoxin Biosynthetic Pathway Indole-Diterpene Biosynthesis in Ascomycetous Fungi Loline and Ergot Alkaloids in Grass Endophytes Biosynthesis of N-methylated peptides in fungi The Molecular Genetics of Lovastatin and Compactin Biosynthesis The Aspergillus nidulans Polyketide Synthase WA FERMENTATION, STRAIN IMPROVEMENT, AND BIOCONVERSION Pneumocandin B0 Production by Fermentation of the Fungus Glarea lozoyensis: Physiological and Engineering Factors Affecting Titer and Structural-Analogue Formation Strain Improvement for the Production of Secondary Metabolites Fungal Bioconversions: Applications to the Manufacture of Pharmaceuticals METABOLIC ENGINEERING Metabolomics Metabolic Engineering Fungal Secondary Metabolic Pathways HETEROLOGOUS PROTEIN AND ENZYME EXPRESSION IN FUNGI Heterologous Protein and Enzyme Expression in Fungi MYCOTOXIN Toxigenic Fungi and Mycotoxin FUNGI IN BIOLOGICAL CONTROL Biochemical Basis of Fungi in Biocontrol of Plant Diseases

Customer Reviews