Cationic antimicrobial peptides are multifunctional peptides of the innate immune system, which not only act directly against microorganisms, but also signal between early and late immune responses and modulate inflammatory reposnes. The significance of these host defence peptides in combating infection and in host-microbe homeostasis has become increasingly clear, through advances made by microbiologists, biochemists, biophysicists, immunologists, molecular biologists, and a range of medical and pharmaceutical researchers. This book, drawing together contributions from leading scientists, reviews significant recent advances in our knowledge of mammalian antimicrobial peptides. In addition to providing up-to-date overviews of their structure, expression and biology, their multiple activities and interactions with microbial populations as well as their potential application as novel therapeutic agents are summarized. Chapters describing developments using animal models and investigations of the roles of these host defence peptides in microbial infections are complemented by chapters addressing their mechanisms of action and of microbial resistance.
1. Overview: antimicrobial peptides, as seen from a rear-view mirror R. I. Lehrer; 2. Cationic antimicrobial peptides in regulation of commensal and pathogenic microbial populations D. A. Devine; 3. Multiple functions of antimicrobial peptides in host immunity D. Yang and J. J. Oppenheim; 4. Therapeutic potential and applications of innate immunity peptides T. J. Falla and L. Zhang; 5. Mammalian I e'Defensins in mucosal defence G. Diamond, D. Laube and M. Klein-Patel; 6. Biology and expression of the human cathelicidin LL-37 G. Gudmundsson and B. Agerberth; 7. Antimicrobial peptides of the alimentary tract of mammals C. Bevins and T. Ganz; 8. Antimicrobial peptides suppress microbial infections and sepsis in animal models K. A. Brogden, M. Ackermann, J. Zabner and M. J. Welsh; 9. Bacterial structure and physiology: influence on susceptibility to antimicrobial peptides R. E. W. Hancock; 9. The antifungal mechanisms of antimicrobial peptides E. J. Helmerhorst and F. G. Oppenheim; 10. Antimicrobial peptides from platelets in defence against cardiovascular infections M. R. Yeaman; 11. Mechanisms of bacterial resistance to antimicrobial peptides R. Tamayo, A. C. Portillo and J. S. Gunn; 12. Roles of antimicrobial peptides in pulmonary disease R. Bals.
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