Books  Data Analysis & Modelling  Data Analysis & Statistics 

Knowledge Discovery in High-Throughput Biological Domains

By: I Jurisica and D Wigle

CRC Press

Hardback | Dec 2005 | #152133 | ISBN: 1584884398
Availability: Usually dispatched within 6 days Details
NHBS Price: £66.99 $87/€78 approx

About this book

Multi-modal representations, the lack of complete and consistent domain theories, rapid evolution of domain knowledge, high dimensionality, and large amounts of missing information - these are challenges inherent in modern proteomics. As our understanding of protein structure and function becomes ever more complicated, we have reached a point where the actual management of data is a major stumbling block to the interpretation of results from proteomic platforms, to knowledge discovery. "Knowledge Discovery in Proteomics" presents timely, authoritative discussions on some of the key issues in high-throughput proteomics, exploring examples that represent some of the major challenges of knowledge discovery in the field. The authors focus on five specific domains: Mass spectrometry-based protein analysis; Protein-protein interaction network analysis; Systematic high-throughput protein crystallization; Systematic, integrated analysis of multiple data repositories; and Systems biology In each area. The authors describe the challenges created by the type of data produced and present potential solutions to the problem of data mining within the domain. They take a systems approach, covering individual data and integrating its computational aspects, from data preprocessing, storage, and access to analysis, visualization, and interpretation. With clear exposition, practical examples, and rich illustrations, this book presents an outstanding overview of this emerging field, and builds the background needed for the fruitful exchange of ideas between computational and biological scientists.


INTRODUCTIONKnowledge DiscoveryProteomicsKNOWLEDGE MANAGEMENTComputational Analysis, Visualization, and Interpretation of HTP Proteomic DataIntroduction to Data ManagementKnowledge ManagementConclusionsCURRENT STATUS AND FUTURE PROSPECTS OF MASS SPECTROMETRYBasic Concepts of Mass SpectrometryMultidimensional ChromatographyProtein QuantitationDetection of Post-Translation ModificationsGlobal Data Analysis, Informatics Resources, and Data MiningGRAPH THEORY ANALYSIS OF PROTEIN-PROTEIN INTERACTIONSGraph Theoretic TerminologyBiological TerminologyLarge Network ModelsProtein Interaction NetworksDetection of Dense SubnetworksConclusionsHTP PROTEIN CRYSTALLIZATION APPROACHESProtein CrystallizationImage Analysis in http Protein CrystallizationCase-based Planning of Crystallization ExperimentsProtein Crystallization Knowledge DiscoveryConclusionsINTEGRATION OF DIVERSE DATA, ALGORITHMS, AND DOMAINSIntegration of Data and ToolsCharacterizing and Predicting Protein-Protein InteractionsApproaches to Data IntegrationConclusionsFROM HIGH-THROUGHPUT TO SYSTEMS BIOLOGYAn Overview of Systems BiologySystematic BiologyProtein-Protein InteractionsModular Biology from Protein Interaction DomainsProtein Interaction NetworksTheoretical Models of Biological SystemsSoftware Development for System ModelingCancer as a System FailureReferences

Write a review

There are currently no reviews for this product. Be the first to review this product!

Bestsellers in this subject

Camera Trapping for Wildlife Research

NHBS Price: £34.99 $45/€41 approx

Statistics for Ecologists Using R and Excel

NHBS Price: £34.99 $45/€41 approx

Choosing and Using Statistics

NHBS Price: £28.10 $36/€33 approx

Data Analysis in Vegetation Ecology

NHBS Price: £42.50 $55/€49 approx

Handbook of Meta-analysis in Ecology and Evolution

NHBS Price: £62.95 $82/€73 approx

VAT: GB 407 4846 44
NHBS Ltd is registered in England and Wales: 1875194