1. General - Models and Techniques. 1. The utility of zebrafish as a model for toxicological research (M.J. Carvan III, T.K. Heiden, H. Tomasiewicz). 2. Use of fish cell lines in the toxicology and ecotoxicology of fish (N.C. Bols et al.). 3. Approaches in proteomics and genomics for eco-toxicology (N.D. Denslow, I. Knoebl, P. Larkin). 2. Biotransformations/Toxicokinetics. 4. Interactions between lipids and persistent organic pollutants (POPs) in fish (A.A. Elskus, T.K. Collier, E. Monosson). 5. Metabolic fate of nonylphenols and related phenolic compounds in fish (J.-P. Cravedi, D. Zalko). 6. Pesticide biotransformation in fish (D. Schlenk). 7. Xenobiotic receptors in fishes: Structural and functional diversity and evolutionary insights (M.E. Hahn, R.R. Merson, S.I. Karchner). 3. Cellular Changes. 8. Impacts of environmental toxicants and natural variables on the immune system of fishes (K.G. Burnett). 9. Fish models of carcinogenesis (G.K. Ostrander, J.M. Rotchell). 10. Metallothionein: structure and regulation (P. Kling, P.-E. Olsson). 11. Cell death: Investigation and application in fish toxicology (A.W. Wood, D.M. Janz, G. van der Kraak). 4. Endocrine Aspects. a. Stress and HPI axis. 12. Stress and the hypothalamo-pituitary-interrenal axis: Adrenal toxicology: effects of environmental pollutants on the structure and function of the HPI axis (A. Hontela). 13. Xenobiotic impact on corticosteroid signaling (M.M. Vijayan, P. Prunet, A.N. Boone). b. Thyroid and Retinoids 14 . Thyroid ormones (J.G. Eales, S.B. Brown). 15. The biology and toxicology of retinoids in fish (D. Alsop et al.). c. Reproduction. 16. Vitellogenesis and endocrine disruption (N. Hiramatsu et al.). 5. Emerging areas. 17. Pharmaceuticals in the environment: Drugged fish? (V.L. Trudeau et al.). 18. P-glycoproteins and xenobiotic efflux transport in fish (A. Sturm, H. Segner). Species Index. Subject Index.