351 pages, Figs, tabs
Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development.
...this little book represents the ever-so-important 'and' that links research and development together in a logical and thoughtful manner...a valuable resource for scientists and clinicians alike... (New England Journal of Medicine, January 27, 2005) "...an excellent publication... I recommended it for libraries...those involved in cancer research...those who teach pharmacy and medical students about drugs used in the treatment of cancer." (The Annals of Pharmacotherapy, December 2004) "...provides an up-to-date overview of the different phases of drug discovery and preclinical development of experimental cancer principles." (Drug Discovery & Development, September 2004) "...a most informative book, discussing the important evolution in the field of cancer therapeutics..." (American Journal of Therapeutics, July/August 2004)
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